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Literature DB >> 3972084

Influence of phenobarbital and TCDD on the hepatic metabolism of TCDD in the dog.

Abstract

The influence of phenobarbital and TCDD pretreatment on the formation and biliary excretion of TCDD-metabolites following single doses of 3H-TCDD was investigated. Without pretreatment, 24.5% of the absorbed 3H-TCDD dose was excreted in the bile within 110 h. Phenobarbital did not influence this rate, whereas a single dose of 10 micrograms of unlabeled TCDD/kg b.wt nine days earlier resulted in a doubling of the amount of radioactive material eliminated in the bile (47.4%).

Entities: Chemical Species

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Year: 1985 PMID： 3972084 DOI： 10.1007/bf02004514

Source DB: PubMed Journal: Experientia ISSN： 0014-4754

10 in total

1. The fate of 2,3,7,8-tetrachlorodibenzo-p-dioxin following single and repeated oral doses to the rat.

Authors: J Q Rose; J C Ramsey; T H Wentzler; R A Hummel; P J Gehring
Journal: Toxicol Appl Pharmacol Date: 1976-05 Impact factor: 4.219

2. 2,3,7,8-Tetrachlorodibenzo-p-dioxin tissue distribution, excretion, and effects on clinical chemical parameters in guinea pigs.

Authors: T A Gasiewicz; R A Neal
Journal: Toxicol Appl Pharmacol Date: 1979-11 Impact factor: 4.219

3. Tissue distribution, excretion, and metabolism of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in the Golden Syrian hamster.

Authors: J R Olson; T A Gasiewicz; R A Neal
Journal: Toxicol Appl Pharmacol Date: 1980-10 Impact factor: 4.219

4. Structure elucidation of mammalian TCDD-metabolites.

Authors: H Poiger; H R Buser; H Weber; U Zweifel; C Schlatter
Journal: Experientia Date: 1982-04-15

5. 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) effects on hepatic microsomal cytochrome P-448-mediated enzyme activities.

Authors: K T Kitchin; J S Woods
Journal: Toxicol Appl Pharmacol Date: 1979-03-15 Impact factor: 4.219

6. The in vivo biotransformation of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in the rat.

Authors: J C Ramsey; J G Hefner; R J Karbowski; W H Braun; P J Gehring
Journal: Toxicol Appl Pharmacol Date: 1982-08 Impact factor: 4.219

7. Effect of alteration of rat hepatic mixed-function oxidase (MFO) activity on the toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD).

Authors: P W Beatty; W K Vaughn; R A Neal
Journal: Toxicol Appl Pharmacol Date: 1978-08 Impact factor: 4.219

1 in total

1. Use of a physiologically based pharmacokinetic model for rats to study the influence of body fat mass and induction of CYP1A2 on the pharmacokinetics of TCDD.

Authors: Claude Emond; Linda S Birnbaum; Michael J DeVito
Journal: Environ Health Perspect Date: 2006-09 Impact factor: 9.031