Literature DB >> 708266

Inhibitory effect of virazole (ribavirin) on the replication of tomato white necrosis virus (VNBT).

G de Fazio, J Caner, M Vicente.   

Abstract

Tomato plants (Lycopersicon esculentum Mill.) inoculated with tomato white necrosis virus (VNBT) and treated with Virazole (1-beta-D-ribofuranosyl--1, 2, 4-triazole-3-carboxamide) at a concentration of 500 mg/l developed systemic virus symptoms in only 40 per cent of the plants in which a remarkable reduction in virus concentration was also observed. From inoculated and Virazole-treated plants which had produced no symptoms, no virus could be recovered. This result suggests that Virazole may inhibit replication of VNBT in tomato.

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Year:  1978        PMID： 708266     DOI： 10.1007/bf01315408

Source DB:  PubMed          Journal:  Arch Virol        ISSN： 0304-8608            Impact factor:   2.574


  7 in total

1.  Regeneration of plants from prtoplasts of potato virus X-infected tobacco leaves. II. Influence of virazole on the frequency of infection.

Authors:  J F Shepard
Journal:  Virology       Date:  1977-05-01       Impact factor: 3.616

2.  Design, synthesis, and broad spectrum antiviral activity of 1- -D-ribofuranosyl-1,2,4-triazole-3-carboxamide and related nucleosides.

Authors:  J T Witkowski; R K Robins; R W Sidwell; L N Simon
Journal:  J Med Chem       Date:  1972-11       Impact factor: 7.446

3.  Broad-spectrum antiviral activity of Virazole: 1-beta-D-ribofuranosyl-1,2,4-triazole-3-carboxamide.

Authors:  R W Sidwell; J H Huffman; G P Khare; L B Allen; J T Witkowski; R K Robins
Journal:  Science       Date:  1972-08-25       Impact factor: 47.728

4.  Inhibition of the replication of influenza A and B viruses by a nucleoside analogue (ribavirin).

Authors:  J S Oxford
Journal:  J Gen Virol       Date:  1975-09       Impact factor: 3.891

5.  Mechanism of action of 1- -D-ribofuranosyl-1,2,4-triazole-3-carboxamide (Virazole), a new broad-spectrum antiviral agent.

Authors:  D G Streeter; J T Witkowski; G P Khare; R W Sidwell; R J Bauer; R K Robins; L N Simon
Journal:  Proc Natl Acad Sci U S A       Date:  1973-04       Impact factor: 11.205

6.  Inhibition of influenza RNA synthesis by virazole (ribavirin).

Authors:  C Scholtissek
Journal:  Arch Virol       Date:  1976       Impact factor: 2.574

7.  Suppression by 1-beta-D-ribofuranosyl-1,2,4-triazole-3-carboxamide (virazole, ICN 1229) of influenza virus-induced infections in mice.

Authors:  G P Khare; R W Sidwell; J T Witkowski; L N Simon; R K Robins
Journal:  Antimicrob Agents Chemother       Date:  1973-04       Impact factor: 5.191
  7 in total
  4 in total

1.  Elimination of Bean yellow mosaic virus from infected cormels of three cultivars of gladiolus using thermo-, electro- and chemotherapy.

Authors:  Charanjeet Kaur; Rashmi Raj; Susheel Kumar; D K Purshottam; Lalit Agrawal; Puneet S Chauhan; S K Raj
Journal:  3 Biotech       Date:  2019-03-26       Impact factor: 2.406

2.  PVX-Cre-mediated marker gene elimination from transgenic plants.

Authors:  L Kopertekh; G Jüttner; J Schiemann
Journal:  Plant Mol Biol       Date:  2004-07       Impact factor: 4.076

3.  Elimination of coexisting canna yellow mottle virus, bean yellow mosaic virus and cucumber mosaic virus from Canna generalis cv. black knight through in vitro chemotherapy of rhizome explants.

Authors:  Aarti Kumari; Susheel Kumar; Puneet Singh Chauhan; S K Raj
Journal:  3 Biotech       Date:  2022-09-08       Impact factor: 2.893

4.  Effect of virazole (ribavirin) on tomato spotted wilt virus in two systemic hosts, tomato and tobacco.

Authors:  G De Fazio; J Caner; M Vicente
Journal:  Arch Virol       Date:  1980       Impact factor: 2.574
  4 in total

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