Literature DB >> 7081219

Evidence for a major dominance component in the variation of serum pepsinogen I levels.

J I Rotter, F L Wong, I M Samloff, K Varis, M Siurala, T Ihamaki, A Ellis, R B McConnell.   

Abstract

We report here a variance component analysis of the distribution of serum pepsinogen I levels in normal individuals, using a maximum-likelihood method on entire pedigrees. The results indicate a broad heritability of 91%, with some 74% being attributed to a dominance component. This is consistent with the hypothesis that the pepsinogen I level in normals is principally determined by the action of major genes, as also seems to be the case for duodenal ulcer patients and families.

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Year:  1982        PMID： 7081219      PMCID： PMC1685324     

Source DB:  PubMed          Journal:  Am J Hum Genet        ISSN： 0002-9297            Impact factor:   11.025


  16 in total

1.  Serum group I pepsinogens by radioimmunoassay in control subjects and patients with peptic ulcer.

Authors:  I M Samloff; W M Liebman; N M Panitch
Journal:  Gastroenterology       Date:  1975-07       Impact factor: 22.682

2.  Extensions to pedigree analysis. III. Variance components by the scoring method.

Authors:  K Lange; J Westlake; M A Spence
Journal:  Ann Hum Genet       Date:  1976-05       Impact factor: 1.670

3.  Estimation of the variance components for dermal ridge count.

Authors:  M A Spence; J Westlake; K Lange
Journal:  Ann Hum Genet       Date:  1977-07       Impact factor: 1.670

4.  Radioimmunoassay of group I pepsinogens in serum.

Authors:  I M Samloff; W M Liebman
Journal:  Gastroenterology       Date:  1974-04       Impact factor: 22.682

5.  Immunologic studies of human group I pepsinogens.

Authors:  I M Samloff
Journal:  J Immunol       Date:  1971-04       Impact factor: 5.422

6.  Cellular localization of group I pepsinogens in human gastric mucosa by immunofluorescence.

Authors:  I M Samloff
Journal:  Gastroenterology       Date:  1971-08       Impact factor: 22.682

7.  Electrophoretic heterogeneity and relationships of pepsinogens in human urine, serum, and gastric mucosa.

Authors:  I M Samloff; P L Townes
Journal:  Gastroenterology       Date:  1970-04       Impact factor: 22.682

8.  Slow moving protease and the seven pepsinogens. Electrophoretic demontration of the existence of eight proteolytic fractions in human gastric mucosa.

Authors:  I M Samloff
Journal:  Gastroenterology       Date:  1969-12       Impact factor: 22.682

Review 9.  Peptic ulcer disease--a heterogeneous group of disorders?

Authors:  J I Rotter; D L Rimoin
Journal:  Gastroenterology       Date:  1977-09       Impact factor: 22.682

10.  Duodenal-ulcer disease associated with elevated serum pepsinogen I: an inherited autosomal dominant disorder.

Authors:  J I Rotter; J Q Sones; I M Samloff; C T Richardson; J M Gursky; J H Walsh; D L Rimoin
Journal:  N Engl J Med       Date:  1979-01-11       Impact factor: 91.245
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  3 in total

1.  Multiplicative effect of hyperpepsinogenemia I and non-secretor status on the risk of duodenal ulcer in siblings.

Authors:  K Sumii; A Inbe; N Uemura; M Kimura; K Haruma; M Yoshihara; H Teshima; K Inoue; H Matsubara; G Kajiyama
Journal:  Gastroenterol Jpn       Date:  1990-04

2.  Pepsinogen I and II expressions in situ and their correlations with serum pesignogen levels in gastric cancer and its precancerous disease.

Authors:  Ping Li; Caiyun He; Liping Sun; Nannan Dong; Yuan Yuan
Journal:  BMC Clin Pathol       Date:  2013-09-02

3.  Serum Pepsinogen Values in Japanese Junior High School Students With Reference to Helicobacter Pylori Infection.

Authors:  Masumi Okuda; Yingsong Lin; Katsuhiro Mabe; Mototsugu Kato; Takako Osaki; Ryosuke Miyamoto; Akihisa Okumura; Shigeru Kamiya; Shogo Kikuchi
Journal:  J Epidemiol       Date:  2019-01-12       Impact factor: 3.211
  3 in total

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