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Literature DB >> 708019

In vitro activity of thienamycin.

Abstract

The in vitro activity of thienamycin was tested against 135 aerobic and anaerobic bacteria. The compound was highly active against resistant gram-negative bacilli and penicillin-resistant Straphylococcus aureus. The antianaerobic spectrum of the drug seemed to be comparable to that of metronidazole.

Entities: Chemical

Mesh：

Substances：

Year: 1978 PMID： 708019 PMCID： PMC352476 DOI： 10.1128/AAC.14.3.436

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

6 in total

1. Susceptibility of anaerobes to cefoxitin and other cephalosporins.

Authors: F P Tally; N V Jacobus; J G Bartlett; S L Gorbach
Journal: Antimicrob Agents Chemother Date: 1975-02 Impact factor: 5.191

2. Activity of cefamandole and other cephalosporins against aerobic and anaerobic bacteria.

Authors: E C Ernst; S Berger; M Barza; N V Jacobus; F P Tally
Journal: Antimicrob Agents Chemother Date: 1976-05 Impact factor: 5.191

3. Bacteroides fragilis resistant to the administration of clindamycin.

Authors: J S Salaki; R Black; F P Tally; J W Kislak
Journal: Am J Med Date: 1976-03 Impact factor: 4.965

Review 4. Therapy for infections due to anaerobic bacteria: an overview.

Authors: S M Finegold
Journal: J Infect Dis Date: 1977-03 Impact factor: 5.226

5. Susceptibility of anaerobic bacteria to 23 antimicrobial agents.

Authors: V L Sutter; S M Finegold
Journal: Antimicrob Agents Chemother Date: 1976-10 Impact factor: 5.191

6. Binding of thienamycin and clavulanic acid to the penicillin-binding proteins of Escherichia coli K-12.

Authors: B G Spratt; V Jobanputra; W Zimmermann
Journal: Antimicrob Agents Chemother Date: 1977-09 Impact factor: 5.191

6 in total

34 in total

1. Thienamycin: new beta-lactam antibiotic with potent broad-spectrum activity.

Authors: S S Weaver; G P Bodey; B M LeBlanc
Journal: Antimicrob Agents Chemother Date: 1979-04 Impact factor: 5.191

Review 2. In vitro and pharmacokinetic properties of the carbapenems.

Authors: R Wise
Journal: Antimicrob Agents Chemother Date: 1986-09 Impact factor: 5.191

3. Penem derivatives: beta-lactamase stability and affinity for penicillin-binding proteins in Escherichia coli.

Authors: S Ohya; Y Utsui; S Sugawara; M Yamazaki
Journal: Antimicrob Agents Chemother Date: 1982-03 Impact factor: 5.191

4. N-formimidoyl thienamycin (MK0787): in vitro activity against anaerobic bacteria.

Authors: D A Martin; C V Sanders; R L Marier
Journal: Antimicrob Agents Chemother Date: 1982-01 Impact factor: 5.191

5. Imipenem-cilastatin as initial therapy for febrile cancer patients.

Authors: G P Bodey; M E Alvarez; P G Jones; K V Rolston; L Steelhammer; V Fainstein
Journal: Antimicrob Agents Chemother Date: 1986-08 Impact factor: 5.191

6. Comparative in vitro activity of N-formimidoyl thienamycin against gram-positive and gram-negative aerobic and anaerobic species and its beta-lactamase stability.

Authors: H C Neu; P Labthavikul
Journal: Antimicrob Agents Chemother Date: 1982-01 Impact factor: 5.191

Review 7. The evolving role of chemical synthesis in antibacterial drug discovery.

Authors: Peter M Wright; Ian B Seiple; Andrew G Myers
Journal: Angew Chem Int Ed Engl Date: 2014-07-02 Impact factor: 15.336

8. In vitro activity of N-formimidoyl thienamycin against 98 clinical isolates of Brucella melitensis compared with those of cefoxitin, rifampin, tetracycline, and co-trimoxazole.

Authors: A Gutiérrez Altés; M Díez Enciso; P Peña García; A Campos Bueno
Journal: Antimicrob Agents Chemother Date: 1982-03 Impact factor: 5.191

9. Phagocytic function and antibody-dependent cellular cytotoxicity of human neutrophils in the presence of N-formimidoyl thienamycin.

Authors: A B Rodriguez; C Barriga; M de la Fuente
Journal: Agents Actions Date: 1990-08

10. In vitro activity of MK0787 (N-formimidoyl thienamycin) and other beta-lactam compounds against Bacteroides spp.

Authors: M Nasu; J P Maskell; R J Williams; J D Williams
Journal: Antimicrob Agents Chemother Date: 1981-10 Impact factor: 5.191