Literature DB >> 708011

Effects of hypoxemia upon aminoglycoside serum pharmacokinetics in animals.

N J Mirhij, R J Roberts, M G Myers.   

Abstract

Hypoxemia causes significant alterations in aminoglycoside serum pharmacokinetics in adult rats and newborn rabbits. The aminoglycoside serum clearances were diminished in hypoxemic animals. Comparisons of intravenous and intramuscular administration imply a delay in uptake of drug from intramuscular injection sites under hypoxemic conditions.

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Year:  1978        PMID： 708011      PMCID： PMC352462          DOI： 10.1128/AAC.14.3.344

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  25 in total

Review 1.  RENAL HEMODYNAMICS.

Authors:  K THURAU
Journal:  Am J Med       Date:  1964-05       Impact factor: 4.965

2.  Effects of low oxygen and of carbon monoxide on the renal circulation in unanesthetized rabbits.

Authors:  P I KORNER
Journal:  Circ Res       Date:  1963-04       Impact factor: 17.367

3.  Effects of gestational age, birth weight, and hypoxemia on pharmacokinetics of amikacin in serum of infants.

Authors:  M G Myers; R J Roberts; N J Mirhij
Journal:  Antimicrob Agents Chemother       Date:  1977-06       Impact factor: 5.191

4.  Clinical pharmacology of carbenicillin and gentamicin in the neonate and comparative efficacy with ampicillin and gentamicin.

Authors:  J D Nelson; G H McCracken
Journal:  Pediatrics       Date:  1973-12       Impact factor: 7.124

5.  Comparative pharmacokinetics of amikacin and kanamycin.

Authors:  J T Clarke; R D Libke; C Regamey; W M Kirby
Journal:  Clin Pharmacol Ther       Date:  1974-06       Impact factor: 6.875

6.  Rapid microassays for clindamycin and gentamicin when present together and the effect of pH and of each on the antibacterial activity of the other.

Authors:  L D Sabath; I Toftegaard
Journal:  Antimicrob Agents Chemother       Date:  1974-07       Impact factor: 5.191

7.  Alteration of effectiveness of antibiotics by anaerobiosis.

Authors:  R M Verklin; G L Mandell
Journal:  J Lab Clin Med       Date:  1977-01

8.  Comparison of serum levels following the administration of oral and parenteral preparations of penicillin to infants and children of various age groups.

Authors:  N N HUANG; R H HIGH
Journal:  J Pediatr       Date:  1953-06       Impact factor: 4.406

9.  Amikacin in newborn infants: comparative pharmacology with kanamycin and clinical efficacy in 45 neonates with bacterial diseases.

Authors:  J B Howard; G H McCraken; H Trujillo; E Mohs
Journal:  Antimicrob Agents Chemother       Date:  1976-08       Impact factor: 5.191

10.  Kinetics and dose calculations of amikacin in the newborn.

Authors:  H Sardemann; H Colding; J Hendel; J P Kampmann; E F Hvidberg; R Vejlsgaard
Journal:  Clin Pharmacol Ther       Date:  1976-07       Impact factor: 6.875
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  2 in total

1.  Effect of pentobarbital anesthesia on amikacin concentrations in plasma and perilymph and evaluation of multiple sampling in perilymph of guinea pigs.

Authors:  S Desjardins-Giasson; A R Beaubien; M J Cauchy
Journal:  Antimicrob Agents Chemother       Date:  1985-05       Impact factor: 5.191

2.  Comparative effects of gentamicin and tobramycin on excretion of N-acetyl-beta-D-glucosaminidase.

Authors:  S T Donta; L A Lembke
Journal:  Antimicrob Agents Chemother       Date:  1985-10       Impact factor: 5.191
  2 in total

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