Literature DB >> 7078549

Thymidylate synthetase - substrate complex formation.

P V Danenberg, A Lockshin.   

Abstract

The complexes that thymidylate synthetase (TSase) forms with various potent inhibitors have been intensively studied and thoroughly reviewed. Of particular significance is the covalent ternary complex of TSase-FdUMP-5,10-CH2H4PteGlu. FdUMP is the active metabolite of the widely used anti-cancer drug 5-fluorouracil. This complex is thought to be analogous to a steady-state intermediate of the normal enzyme reaction with the substrate dUMP. In this review, we examine the properties of TSase-dUMP complexes in order to determine if there is an experimental basis for drawing a close analogy between dUMP and FdUMP in their interaction with TSase, and also to evaluate data indicating a potential chemotherapeutic value for TSase-dUMP complexes formed in the presence of folate analogs.

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Year:  1982        PMID： 7078549     DOI： 10.1007/bf00229539

Source DB:  PubMed          Journal:  Mol Cell Biochem        ISSN： 0300-8177            Impact factor:   3.396


  44 in total

1.  THE MODE OF ACTION OF 5-FLUOROURACIL AND ITS DERIVATIVES.

Authors:  S S Cohen; J G Flaks; H D Barner; M R Loeb; J Lichtenstein
Journal:  Proc Natl Acad Sci U S A       Date:  1958-10-15       Impact factor: 11.205

2.  Essential arginyl residues in thymidylate synthetase.

Authors:  K L Cipollo; R B Dunlap
Journal:  Biochem Biophys Res Commun       Date:  1978-04-28       Impact factor: 3.575

3.  Demonstration of separate binding sites for the folate coenzymes and deoxynucleotides with inactivated Lactobacillus casei thymidylate synthetase.

Authors:  J H Galivan; F Maley; C M Baugh
Journal:  Biochem Biophys Res Commun       Date:  1976-07-26       Impact factor: 3.575

4.  Thymidylate synthetase: fluorine-19 nmr characterization of the active site peptide covalently bound to 5-fluoro-2'-deoxyuridylate and 5,10-methylenetetrahydrofolate.

Authors:  T L James; A L Pogolotti; K M Ivanetich; Y Wataya; S S Lam; D V Santi
Journal:  Biochem Biophys Res Commun       Date:  1976-09-20       Impact factor: 3.575

5.  Nalpha-(pteroyltetra (gamma-glutamyl))-lysine as a ligand for the purification of thymidylate synthetase by affinity chromatography.

Authors:  L T Plante; Y Gaumont; R L Kisliuk
Journal:  Prep Biochem       Date:  1978

6.  Mechanism of interaction of thymidylate synthetase with 5-fluorodeoxyuridylate.

Authors:  D V Santi; C S McHenry; H Sommer
Journal:  Biochemistry       Date:  1974-01-29       Impact factor: 3.162

7.  The purification and properties of thymidylate synthetase from chick embryo extracts.

Authors:  M Y Lorenson; G F Maley; F Maley
Journal:  J Biol Chem       Date:  1967-07-25       Impact factor: 5.157

8.  Factors affecting substrate binding in Lactobacillus casei thymidylate synthetase as studied by equilibrium dialysis.

Authors:  J H Galivan; G F Maley; F Maley
Journal:  Biochemistry       Date:  1976-01-27       Impact factor: 3.162

9.  Interaction of deoxyuridylate with thymidylate synthetase.

Authors:  R P Leary; N Beaudette; R L Kisliuk
Journal:  J Biol Chem       Date:  1975-07-10       Impact factor: 5.157

10.  Purification of thymidylate synthetase from enzyme-poor sources by affinity chromatography.

Authors:  K Slavík; W Rode; V Slavíková
Journal:  Biochemistry       Date:  1976-09-21       Impact factor: 3.162
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  3 in total

1.  Functional interaction between fluorodeoxyuridine-induced cellular alterations and replication of a ribonucleotide reductase-negative herpes simplex virus.

Authors:  H Petrowsky; G D Roberts; D A Kooby; B M Burt; J J Bennett; K A Delman; S F Stanziale; T M Delohery; W P Tong; H J Federoff; Y Fong
Journal:  J Virol       Date:  2001-08       Impact factor: 5.103

2.  Phase I study of 5-fluorouracil in children and young adults with recurrent ependymoma.

Authors:  Karen D Wright; Vinay M Daryani; David C Turner; Arzu Onar-Thomas; Nidal Boulos; Brent A Orr; Richard J Gilbertson; Clinton F Stewart; Amar Gajjar
Journal:  Neuro Oncol       Date:  2015-11-04       Impact factor: 12.300

3.  Sequential methotrexate/5-FU: FdUMP formation and TS inhibition in a transplantable rodent colon adenocarcinoma.

Authors:  M H Berne; B G Gustavsson; O Almersjö; P C Spears; R Frösing
Journal:  Cancer Chemother Pharmacol       Date:  1986       Impact factor: 3.333
  3 in total

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