Literature DB >> 7078361

The lipid composition of human liver microsomes.

L Waskell, D Koblin, E Canova-Davis.   

Abstract

The lipid composition of human liver microsomes isolated from liver biopsy samples obtained at abdominal surgery has been determined. Human liver microsomal phospholipid is composed of 49% phosphatidylcholine, 31% phosphatidylethanolamine, 14% phosphatidylserine + phosphatidylinositol and 6% sphingomyelin, very similar to the phospholipid composition of rat liver microsomes. The fatty acid composition of human liver microsomes is remarkable only for its content of polyunsaturated fatty acids, with 20% of the fatty acids consisting of arachidonic, docosatetraenoic, docosapentaenoic and docosahexaenoic acids. This value contrasts with 33% in rats and 9% in rabbits. The molar cholesterol/phospholipid ratio in human liver microsomes is 0.069, similar to the ratio in rat and rabbit microsomes.

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Year:  1982        PMID： 7078361     DOI： 10.1007/bf02534948

Source DB:  PubMed          Journal:  Lipids        ISSN： 0024-4201            Impact factor:   1.880


  13 in total

1.  Sex difference in the phospholipid composition of rat liver microsomes.

Authors:  H Belina; S D Cooper; R Farkas; G Feuer
Journal:  Biochem Pharmacol       Date:  1975-01-15       Impact factor: 5.858

2.  Quantitative analysis of phospholipids by thin-layer chromatography and phosphorus analysis of spots.

Authors:  G Rouser; A N Siakotos; S Fleischer
Journal:  Lipids       Date:  1966-01       Impact factor: 1.880

3.  An effect of estradiol and testosterone on the calcium pump activity and phospholipid fatty acid composition of rat liver microsomes.

Authors:  L Moore; H R Knapp; E J Landon
Journal:  Endocrinology       Date:  1977-06       Impact factor: 4.736

4.  Reduced triphosphopyridine nucleotide oxidase-catalyzed alterations of membrane phospholipids. I. Nature of the lipid alterations.

Authors:  H E May; P B McCay
Journal:  J Biol Chem       Date:  1968-05-10       Impact factor: 5.157

5.  Enzymic characterization and lipid composition of rat liver subcellular membranes.

Authors:  A Colbeau; J Nachbaur; P M Vignais
Journal:  Biochim Biophys Acta       Date:  1971-12-03

6.  Drug metabolism in human liver in vitro: establishment of a human liver bank.

Authors:  C von Bahr; C G Groth; H Jansson; G Lundgren; M Lind; H Glaumann
Journal:  Clin Pharmacol Ther       Date:  1980-06       Impact factor: 6.875

7.  The rate of pentobarbital and acetanilide metabolism by liver microsomes: a function of lipid peroxidation and degradation of cytochrome P-450 heme.

Authors:  M Jacobson; W Levin; A Y Lu; A H Conney; R Kuntzman
Journal:  Drug Metab Dispos       Date:  1973 Nov-Dec       Impact factor: 3.922

8.  Lipid peroxidation and the degradation of cytochrome P-450 heme.

Authors:  W Levin; A Y Lu; M Jacobson; R Kuntzman; J L Poyer; P B McCay
Journal:  Arch Biochem Biophys       Date:  1973-10       Impact factor: 4.013

9.  Energy-dependent calcium sequestration activity in rat liver microsomes.

Authors:  L Moore; T Chen; H R Knapp; E J Landon
Journal:  J Biol Chem       Date:  1975-06-25       Impact factor: 5.157

10.  PREPARATION OF FATTY ACID METHYL ESTERS AND DIMETHYLACETALS FROM LIPIDS WITH BORON FLUORIDE--METHANOL.

Authors:  W R MORRISON; L M SMITH
Journal:  J Lipid Res       Date:  1964-10       Impact factor: 5.922
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  4 in total

1.  Fluorescence formation from hydroperoxide of phosphatidylcholine with amino compound.

Authors:  T Iio; K Yoden
Journal:  Lipids       Date:  1988-01       Impact factor: 1.880

Review 2.  Cytochrome P450 Organization and Function Are Modulated by Endoplasmic Reticulum Phospholipid Heterogeneity.

Authors:  Lauren M Brignac-Huber; Ji Won Park; James R Reed; Wayne L Backes
Journal:  Drug Metab Dispos       Date:  2016-05-27       Impact factor: 3.922

3.  Competitive inhibition of bile acid synthesis by endogenous cholestanol and sitosterol in sitosterolemia with xanthomatosis. Effect on cholesterol 7 alpha-hydroxylase.

Authors:  S Shefer; G Salen; L Nguyen; A K Batta; V Packin; G S Tint; S Hauser
Journal:  J Clin Invest       Date:  1988-12       Impact factor: 14.808

4.  Microsomal cytochrome P-450-linked monooxygenase systems and lipid composition of human hepatocellular carcinoma.

Authors:  I Hamamoto; S Tanaka; T Maeba; K Chikaishi; Y Ichikawa
Journal:  Br J Cancer       Date:  1989-01       Impact factor: 7.640
  4 in total

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