Literature DB >> 7073987

Inactivation of Kell blood group antigens by 2-aminoethylisothiouronium bromide.

H Advani, J Zamor, W J Judd, C L Johnson, W L Marsh.   

Abstract

Human red cells incubated with a solution containing 6% 2-aminoethylisothiouronium bromide (AET) lose activity of antigens that are part of, or related to, the Kell blood group system. However, Kx antigen is not inactivated. Studies on a wide range of other blood-group antigens show no other evidence of changes and AET appears to react specifically with red-cell membrane structures that have Kell activity. The AET procedure produces an artificial K0 red cell that can be used in blood group serology, and allows easy recognition of antibodies that are associated with the Kell system. AET has been used by other workers to produce a red cell that has many serological and biochemical characteristics of a PNH cell. Our studies on red cells from PNH patients have not shown any changes in Kell blood-group antigens.

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Year:  1982        PMID： 7073987     DOI： 10.1111/j.1365-2141.1982.tb07295.x

Source DB:  PubMed          Journal:  Br J Haematol        ISSN： 0007-1048            Impact factor:   6.998


  8 in total

1.  Molecular cloning and primary structure of Kell blood group protein.

Authors:  S Lee; E D Zambas; W L Marsh; C M Redman
Journal:  Proc Natl Acad Sci U S A       Date:  1991-07-15       Impact factor: 11.205

2.  Immune hemolytic anemia and renal failure associated with rifampicin-dependent antibodies with anti-I specificity.

Authors:  A Pereira; C Sanz; F Cervantes; R Castillo
Journal:  Ann Hematol       Date:  1991-07       Impact factor: 3.673

3.  A human cell-surface glycoprotein that carries Cromer-related blood group antigens on erythrocytes and is also expressed on leucocytes and platelets.

Authors:  F A Spring; P A Judson; G L Daniels; S F Parsons; G Mallinson; D J Anstee
Journal:  Immunology       Date:  1987-10       Impact factor: 7.397

4.  Identification of a cell-surface antigen produced by a gene on human chromosome 3 (cen-q22) and not expressed by Rhnull cells.

Authors:  Y E Miller; G L Daniels; C Jones; D K Palmer
Journal:  Am J Hum Genet       Date:  1987-12       Impact factor: 11.025

5.  New monoclonal antibodies in CD59: use for the analysis of peripheral blood cells from paroxysmal nocturnal haemoglobinuria (PNH) patients and for the quantitation of CD59 on normal and decay accelerating factor (DAF)-deficient erythrocytes.

Authors:  A Fletcher; J A Bryant; B Gardner; P A Judson; F A Spring; S F Parsons; G Mallinson; D J Anstee
Journal:  Immunology       Date:  1992-03       Impact factor: 7.397

6.  The Ina and Inb blood group antigens are located on a glycoprotein of 80,000 MW (the CDw44 glycoprotein) whose expression is influenced by the In(Lu) gene.

Authors:  F A Spring; R Dalchau; G L Daniels; G Mallinson; P A Judson; S F Parsons; J W Fabre; D J Anstee
Journal:  Immunology       Date:  1988-05       Impact factor: 7.397

7.  The quantification of erythrocyte antigen sites with monoclonal antibodies.

Authors:  A H Merry; E E Thomson; D J Anstee; F Stratton
Journal:  Immunology       Date:  1984-04       Impact factor: 7.397

8.  Biochemical and genetic analysis of the OKa blood group antigen.

Authors:  B P Williams; G L Daniels; B Pym; D Sheer; S Povey; Y Okubo; P W Andrews; P N Goodfellow
Journal:  Immunogenetics       Date:  1988       Impact factor: 2.846
  8 in total

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