| Literature DB >> 3679286 |
F A Spring1, P A Judson, G L Daniels, S F Parsons, G Mallinson, D J Anstee.
Abstract
A new human erythrocyte glycoprotein has been identified by immunoblotting with murine monoclonal antibodies under non-reducing conditions. The glycoprotein has a MW of 70,000 and carries Cromer-related blood group antigens. The monoclonal antibodies also react with normal peripheral blood leucocytes and platelets and several haemopoietic cell lines. The glycoprotein has a reduced MW after sialidase treatment. The MW is markedly reduced in Tn erythrocyte membranes and slightly increased in Cad erythrocyte membranes. These results suggest that the glycoprotein has a substantial content of O-glycans. The glycoprotein appears to be absent from, or grossly altered in, the erythrocytes of two individuals with the rare Inab phenotype.Entities:
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Year: 1987 PMID: 3679286 PMCID: PMC1453983
Source DB: PubMed Journal: Immunology ISSN: 0019-2805 Impact factor: 7.397