| Literature DB >> 70686 |
C E Niehaus, A Nicoll, R Wootton, B Williams, J Lewis, D J Coltart, B Lewis.
Abstract
Transfer of low-density lipoprotein (L.D.L.2) from plasma to arterial intima was studied in 16 patients undergoing arterial surgery. Autologous labelled lipoprotein was used to demonstrate that L.D.L.2 enters the intima from plasma. Net flux of L.D.L.2 appeared to increase with age. Within each age-group the net flux of L.D.L.2 showed a pronounced positive correlation with plasma-L.D.L.-cholesterol concentrations. This may account in part for the association between hypercholesterolaemia and the development of atherosclerosis.Entities:
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Year: 1977 PMID： 70686 DOI： 10.1016/s0140-6736(77)91600-2
Source DB: PubMed Journal: Lancet ISSN： 0140-6736 Impact factor: 79.321