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Literature DB >> 7066900

Evidence for single-cell origin of 3-methylcholanthrene-induced fibrosarcomas in mice with cellular mosaicism.

Abstract

Fibrosarcomas produced by s.c. injection of 5 micrograms of 3-methylcholanthrene in Pgk-1a/Pgk-1b mice carrying X-chromosome inactivation mosaicism for the phosphoglycerate kinase (PGK-1) gene contained only one type of phosphoglycerate kinase in seven of eight cases (88%), as judged from its electrophoretic mobility, indicating the single-cell origin of the tumor.

Entities: Chemical Disease Gene Species

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Year: 1982 PMID： 7066900

Source DB: PubMed Journal: Cancer Res ISSN： 0008-5472 Impact factor: 12.701

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Cited

8 in total

1. Tumor heterogeneity: biological implications and therapeutic consequences.

Authors: G H Heppner; B E Miller
Journal: Cancer Metastasis Rev Date: 1983 Impact factor: 9.264

2. The selective nature of metastasis.

Authors: J E Talmadge
Journal: Cancer Metastasis Rev Date: 1983 Impact factor: 9.264

Review 3. Intratumor immunologic heterogeneity.

Authors: F R Miller
Journal: Cancer Metastasis Rev Date: 1982 Impact factor: 9.264

4. Enhanced tumorigenicity of cloned UV-regressor tumor lines following selected in vivo and in vitro manipulations.

Authors: M K Schmitt; L K Roberts; L C Gahring; R A Daynes
Journal: Am J Pathol Date: 1983-12 Impact factor: 4.307

5. Macroscopic intestinal colonies of mice as a tool for studying differentiation of multipotential intestinal stem cells.

Authors: M Inoue; M Imada; Y Fukushima; N Matsuura; H Shiozaki; T Mori; Y Kitamura; H Fujita
Journal: Am J Pathol Date: 1988-07 Impact factor: 4.307

Evidence for single-cell origin of 3-methylcholanthrene-induced fibrosarcomas in mice with cellular mosaicism.

1. Tumor heterogeneity: biological implications and therapeutic consequences.

2. The selective nature of metastasis.

Review 3. Intratumor immunologic heterogeneity.

4. Enhanced tumorigenicity of cloned UV-regressor tumor lines following selected in vivo and in vitro manipulations.

5. Macroscopic intestinal colonies of mice as a tool for studying differentiation of multipotential intestinal stem cells.

6. Clonal origin of mouse liver cell tumors.

Review 7. Monoclonal growth of cancer cells: experimental evidence.

8. Clonal origin of skin and bone tumors produced by repeated beta-irradiation in mosaic cell mice.