Literature DB >> 7062236

High-pressure liquid chromatographic analysis of indocyanine green.

P L Rappaport, J J Thiessen.   

Abstract

The development of a specific high-pressure liquid chromatographic (HPLC) assay, having a quantitative detection limit of 0.4 microgram/ml, is described for plasma indocyanine green. In a preliminary study, the HPLC method demonstrated that te traditional spectrophotometric procedure inaccurately quantitates the dye's degradation in aqueous medium since degradation products that absorb light at 770- nm are formed. In a further study, the spectrophotometric method yielded an erroneously low clearance of indocyanine green in the rabbit. In addition, the HPLC assay points to the possibility of metabolite formation of the dye in vivo.

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Year:  1982        PMID： 7062236     DOI： 10.1002/jps.2600710205

Source DB:  PubMed          Journal:  J Pharm Sci        ISSN： 0022-3549            Impact factor:   3.534


  10 in total

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Authors:  B Crotty; K J Watson; P V Desmond; M L Mashford; L J Wood; J Colman; F J Dudley
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4.  Pharmacokinetics of biliary excretion in man. VI. Indocyanine green.

Authors:  D K Meijer; B Weert; G A Vermeer
Journal:  Eur J Clin Pharmacol       Date:  1988       Impact factor: 2.953

5.  Interaction study between nifedipine and recombinant tissue-type plasminogen activator in healthy subjects.

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6.  Effects of advanced leukemia on hepatic drug-metabolizing activity in the mouse.

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Authors:  M L Martin; M D Jensen
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9.  Experimental impact of assay-dependent differences in plasma indocyanine green concentration determinations.

Authors:  D M Grasela; M L Rocci; P H Vlasses
Journal:  J Pharmacokinet Biopharm       Date:  1987-12

10.  Effects of duration of ischemia and donor pretreatment with methylprednisolone or its macromolecular prodrug on the disposition of indocyanine green in cold-preserved rat livers.

Authors:  Anjaneya P Chimalakonda; Reza Mehvar
Journal:  Pharm Res       Date:  2004-06       Impact factor: 4.200
  10 in total

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