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Literature DB >> 7059465

Decrease in tumour growth by injections of histamine or serotonin in fibrosarcoma-bearing mice: influence of H1 and H2 histamine receptors.

C Burtin, P Scheinmann, J C Salomon, G Lespinats, P Canu.

Abstract

C3H and C57 BL/6 mice carrying methylcholanthrene-induced fibrosarcomas were injected i.p. daily with histamine, metiamide (anti-histamine type-2 receptor), histamine + metiamide, mepyramine (anti-histamine type-1 receptor), serotonin and methysergide (anti-serotonin). Inhibition of tumour growth and lengthened survival were observed with histamine and histamine + metiamide. The best results (both on tumour growth and survival) were obtained with serotonin. Survival was increased by metiamide and decreased by mepyramine and methysergide. In histamine-treated and in serotonin-treated mice, histological studies of the tumours showed large and numerous foci of haemorrhagic necrosis. Stimulation of histamine type-1 or serotonin receptors and inhibition of histamine type-2 receptors play a beneficial role in the host's defence against tumours.

Entities: Chemical Disease Species

Mesh：

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Year: 1982 PMID： 7059465 PMCID： PMC2010957 DOI： 10.1038/bjc.1982.7

Source DB: PubMed Journal: Br J Cancer ISSN： 0007-0920 Impact factor: 7.640

16 in total

1. Studies on the mechanism of lymphocyte-mediated cytolysis. IV. Specificity of the histamine receptor on effector T cells.

Authors: M Plaut; L M Lichtenstein; E Gillespie; C S Henney
Journal: J Immunol Date: 1973-08 Impact factor: 5.422

2. Tumour-associated inhibition of immediate hypersensitivity reactions in mice.

Authors: N R Lynch; J C Salomon
Journal: Immunology Date: 1977-05 Impact factor: 7.397

3. Mouse mast cells as anti-tumor effector cells.

Authors: E Farram; D S Nelson
Journal: Cell Immunol Date: 1980-10 Impact factor: 4.868

4. Immunity to a 3-methylcholanthrene-induced fibrosarcoma in the C57BL/6 mouse: in vivo analysis by the adoptive tumor neutralization test.

Authors: M F Poupon; G Lespinats; J P Kolb; B Payelle
Journal: J Natl Cancer Inst Date: 1979-04 Impact factor: 13.506

5. Passive local anaphylaxis: demonstration of antitumor activity and complementation of intratumor BCG.

Authors: N R Lynch; J C Salomon
Journal: J Natl Cancer Inst Date: 1977-04 Impact factor: 13.506

6. Tumor-basophil interactions in vitro--a scanning and transmission electron microscopic study.

Authors: A M Dvorak; S J Galli; A S Galli; M E Hammond; W H Churchill; H F Dvorak
Journal: J Immunol Date: 1979-06 Impact factor: 5.422

7. Characterization of the human blood lymphocytes that produce a histamine-induced suppressor factor (HSF).

Authors: R E Rocklin; J Breard; S Gupta; R A Good; K L Melmon
Journal: Cell Immunol Date: 1980-05 Impact factor: 4.868

8. Histamine levels in blood and other tissues of male and female C3H mice. II. Mice carrying a 3-methyl-cholanthrene-induced tumor [proceedings].

Authors: P Scheinmann; B Lebel; N R Lynch; J C Salomon; J R Paupe; C Burtin
Journal: Agents Actions Date: 1979-04

9. The effect of locally injected vasoactive amines on the elicitation of delayed-type hypersensitivity.

Authors: A Schwartz; P W Askenase; R K Gershon
Journal: J Immunol Date: 1977-01 Impact factor: 5.422

10. Mechanism of inhibition of tumour growth by aspirin and indomethacin.

Authors: N R Lynch; M Castes; M Astoin; J C Salomon
Journal: Br J Cancer Date: 1978-10 Impact factor: 7.640

26 in total

Review 1. IgE and immune defense mechanism.

Authors: J P Dessaint; A Capron
Journal: Clin Rev Allergy Date: 1989

Decrease in tumour growth by injections of histamine or serotonin in fibrosarcoma-bearing mice: influence of H1 and H2 histamine receptors.

1. Studies on the mechanism of lymphocyte-mediated cytolysis. IV. Specificity of the histamine receptor on effector T cells.

2. Tumour-associated inhibition of immediate hypersensitivity reactions in mice.

3. Mouse mast cells as anti-tumor effector cells.

4. Immunity to a 3-methylcholanthrene-induced fibrosarcoma in the C57BL/6 mouse: in vivo analysis by the adoptive tumor neutralization test.

5. Passive local anaphylaxis: demonstration of antitumor activity and complementation of intratumor BCG.

6. Tumor-basophil interactions in vitro--a scanning and transmission electron microscopic study.

7. Characterization of the human blood lymphocytes that produce a histamine-induced suppressor factor (HSF).

8. Histamine levels in blood and other tissues of male and female C3H mice. II. Mice carrying a 3-methyl-cholanthrene-induced tumor [proceedings].

9. The effect of locally injected vasoactive amines on the elicitation of delayed-type hypersensitivity.

10. Mechanism of inhibition of tumour growth by aspirin and indomethacin.

Review 1. IgE and immune defense mechanism.

Review 2. Biological effects of histamine: an overview.

3. Antitumor properties of histamine in vivo.

4. Growth inhibition of murine mammary carcinoma by monoclonal IgE antibodies specific for the mammary tumor virus.

5. Acute hemodynamic effects of an antitumoral agent: elliptinium. Involvement of histamine release.

6. The effect of H2 antagonists on proliferation and apoptosis in human colorectal cancer cell lines.

7. Cardiac and vascular effects of elliptinium in guinea pigs. Involvement of a histaminergic mechanism.

8. Effect of histamine on the growth of human gastrointestinal tumours: reversal by cimetidine.

9. Changes in histamine synthesis, tissue content and catabolism in human breast cancer.

10. In vivo and in vitro anti-tumour activity of dimaprit.