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Literature DB >> 2750594

Changes in histamine synthesis, tissue content and catabolism in human breast cancer.

M Garcia-Caballero¹, E Neugebauer, F Rodriguez, I Nuñez de Castro, A Heredia, E Oosting, C Vara Thorbeck.

Abstract

The present study in 10 breast cancer patients supports the concept that newly synthetized, nascent histamine is involved in tumour growth. Histidine decarboxylase (HDC) activity is increased in mammary tumour tissue compared to healthy mammary gland-, skin- and muscle tissue in all but one patient studied. The newly formed histamine is probably not stored in the tumour tissue. Significantly decreased histamine concentrations were measured in parallel samples in the tumour tissue. Moreover, the preliminary results from urinary analysis of histamine and N tau-methylhistamine in 3 of the 10 patients studied showed a significant decline after tumour extirpation compared to preoperative values.

Entities: Chemical Disease Gene Species

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Year: 1989 PMID： 2750594 DOI： 10.1007/bf02222247

Source DB: PubMed Journal: Agents Actions ISSN： 0065-4299

10 in total

1. Increase in histidine decarboxylase activity in mouse skin after application of the tumor promoter tetradecanoylphorbol acetate.

Authors: T Watanabe; Y Taguchi; K Sasaki; K Tsuyama; Y Kitamura
Journal: Biochem Biophys Res Commun Date: 1981-05-15 Impact factor: 3.575

2. Clinical improvement in advanced cancer disease after treatment combining histamine and H2-antihistaminics (ranitidine or cimetidine).

Authors: C Burtin; C Noirot; P Scheinmann; L Galoppin; D Sabolovic; P Bernard
Journal: Eur J Cancer Clin Oncol Date: 1988-02

3. A modified Schayer procedure for the estimation of histidine decarboxylase activity: its application on tissue extracts from gastric mucosa of various mammals.

Authors: E Neugebauer; W Lorenz
Journal: Agents Actions Date: 1982-04

4. Histamine content, diamine oxidase activity and histamine methyltransferase activity in human tissues: fact or fictions?

Authors: R Hesterberg; J Sattler; W Lorenz; C D Stahlknecht; H Barth; M Crombach; D Weber
Journal: Agents Actions Date: 1984-04

5. The influence of intraperitoneal injections of histamine on tumour growth in fibrosarcoma-bearing mice.

Authors: C Burtin; P Scheinmann; J C Salomon; G Lespinats; F Loisillier; P Canu
Journal: Cancer Lett Date: 1981-04 Impact factor: 8.679

6. Involvement of histamine in growth of mouse and rat tumors: antitumoral properties of monofluoromethylhistidine, an enzyme-activated irreversible inhibitor of histidine decarboxylase.

Authors: J Bartholeyns; M Bouclier
Journal: Cancer Res Date: 1984-02 Impact factor: 12.701

7. Age dependent normal values of histamine and histamine metabolites in human urine.

Authors: E Oosting; J J Keyzer; B G Wolthers; R J Scholtis
Journal: Agents Actions Date: 1988-04

8. Increased histidine decarboxylase (HDC) activity in human colorectal cancer: results of a study on ten patients.

Authors: M Garcia-Caballero; E Neugebauer; R Campos; I Nunez de Castro; C Vara-Thorbeck
Journal: Agents Actions Date: 1988-04

9. Increased tissue histamine in tumour-bearing mice and rats.

Authors: C Burtin; P Scheinmann; J C Salomon; G Lespinats; C Frayssinet; B Lebel; P Canu
Journal: Br J Cancer Date: 1981-05 Impact factor: 7.640

10. Decrease in tumour growth by injections of histamine or serotonin in fibrosarcoma-bearing mice: influence of H1 and H2 histamine receptors.

Authors: C Burtin; P Scheinmann; J C Salomon; G Lespinats; P Canu
Journal: Br J Cancer Date: 1982-01 Impact factor: 7.640

10 in total

7 in total

1. Chlorpheniramine inhibits the synthesis of ornithine decarboxylase and the proliferation of human breast cancer cell lines.

Authors: M A Medina; R García de Veas; P Morata; J Lozano; F Sánchez-Jiménez
Journal: Breast Cancer Res Treat Date: 1995-08 Impact factor: 4.872

Changes in histamine synthesis, tissue content and catabolism in human breast cancer.

1. Increase in histidine decarboxylase activity in mouse skin after application of the tumor promoter tetradecanoylphorbol acetate.

2. Clinical improvement in advanced cancer disease after treatment combining histamine and H2-antihistaminics (ranitidine or cimetidine).

3. A modified Schayer procedure for the estimation of histidine decarboxylase activity: its application on tissue extracts from gastric mucosa of various mammals.

4. Histamine content, diamine oxidase activity and histamine methyltransferase activity in human tissues: fact or fictions?

5. The influence of intraperitoneal injections of histamine on tumour growth in fibrosarcoma-bearing mice.

6. Involvement of histamine in growth of mouse and rat tumors: antitumoral properties of monofluoromethylhistidine, an enzyme-activated irreversible inhibitor of histidine decarboxylase.

7. Age dependent normal values of histamine and histamine metabolites in human urine.

8. Increased histidine decarboxylase (HDC) activity in human colorectal cancer: results of a study on ten patients.

9. Increased tissue histamine in tumour-bearing mice and rats.

10. Decrease in tumour growth by injections of histamine or serotonin in fibrosarcoma-bearing mice: influence of H1 and H2 histamine receptors.

1. Chlorpheniramine inhibits the synthesis of ornithine decarboxylase and the proliferation of human breast cancer cell lines.

2. Effect of histamine on growth and differentiation of the rat mammary gland.

3. Histamine in C3H/W mice carrying spontaneous tumors of the mammary gland.

4. Decreased histamine content and metabolism in mammary cancer tissue from C3H mice.

5. Histamine as an autocrine growth factor in experimental mammary carcinomas.

6. Exometabolom analysis of breast cancer cell lines: Metabolic signature.

7. Metabolic signature of breast cancer cell line MCF-7: profiling of modified nucleosides via LC-IT MS coupling.