Literature DB >> 70591

Levamisole in the treatment of Crohn's disease.

A W Segal, A J Levi, G Loewi.   

Abstract

In 8 patients with active uncomplicated Crohn's disease who were not receiving any specific therapy, a clinical remission was induced with an elemental diet, and then an attempt was made to maintain this remission with levamisole. This regimen resulted in excellent control of the disease. A drug-induced arthritis developed in two patients and resolved spontaneously. There were no other significant side-effects.

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Year:  1977        PMID: 70591     DOI: 10.1016/s0140-6736(77)90307-5

Source DB:  PubMed          Journal:  Lancet        ISSN: 0140-6736            Impact factor:   79.321


  10 in total

Review 1.  Review of general surgery 1977.

Authors:  H Ellis
Journal:  Postgrad Med J       Date:  1978-06       Impact factor: 2.401

2.  Oral BCG vaccine in Crohn's disease.

Authors:  W R Burnham; J E Lennard-Jones; P Hecketsweiler; R Colin; Y Geffroy
Journal:  Gut       Date:  1979-03       Impact factor: 23.059

3.  The in vitro evaluation of certain neutrophil and lymphocyte functions following the ingestion of 150 mg oral dose of levamisole: assessment of the extent and duration of stimulation of neutrophil chemotaxis, protein iodination and lymphocyte transformation.

Authors:  R Anderson; R Oosthuizen; A Theron; A J Van Rensburg
Journal:  Clin Exp Immunol       Date:  1979-03       Impact factor: 4.330

Review 4.  Idiopathic Inflammation Bowel Disease: is there a role for immunological mechanisms in etiopathogenesis?

Authors:  R G Shorter
Journal:  Gastroenterol Jpn       Date:  1982-10

5.  Elemental diet in acute Crohn's disease.

Authors:  C O'Moráin; A M Segal; A J Levi; H B Valman
Journal:  Arch Dis Child       Date:  1983-01       Impact factor: 3.791

6.  Elemental diet as primary treatment of acute Crohn's disease: a controlled trial.

Authors:  C O'Moráin; A W Segal; A J Levi
Journal:  Br Med J (Clin Res Ed)       Date:  1984-06-23

7.  Controlled therapeutic trial of levamisole and sulphasalazine in acute ulcerative colitis.

Authors:  A Hermanowicz; A Nowak; L Gajos
Journal:  Gut       Date:  1984-05       Impact factor: 23.059

8.  Elemental diets in treatment of acute Crohn's disease.

Authors:  C O'Morain; A W Segal; A J Levi
Journal:  Br Med J       Date:  1980-11-01

Review 9.  What is wrong with granulocytes in inflammatory bowel diseases?

Authors:  Adam P Levine; Anthony W Segal
Journal:  Dig Dis       Date:  2013-11-14       Impact factor: 2.404

Review 10.  Making sense of the cause of Crohn's - a new look at an old disease.

Authors:  Anthony W Segal
Journal:  F1000Res       Date:  2016-10-12
  10 in total

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