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Literature DB >> 374194

Oral BCG vaccine in Crohn's disease.

W R Burnham, J E Lennard-Jones, P Hecketsweiler, R Colin, Y Geffroy.

Abstract

In a randomised double-blind trial over one year oral BCG has been compared with a control preparation in the treatment of chronic Crohn's disease. Overall assessment scores deteriorated in nine of 22 patients taking BCG, and 11 of 26 in the control group (P = 0.25); this deterioration was great enough to be regarded as a clinical relapse in three patients taking BCG and in seven taking the control preparation (P greater than 0.1). No significant benefit from oral BCG treatment has been demonstrated.

Entities: Disease Species

Mesh：

Substances：
BCG Vaccine

Year: 1979 PMID： 374194 PMCID： PMC1412307 DOI： 10.1136/gut.20.3.229

Source DB: PubMed Journal: Gut ISSN： 0017-5749 Impact factor: 23.059

9 in total

7 in total

Review 1. Is Crohn's disease an immunodeficiency? A hypothesis suggesting possible early events in the pathogenesis of Crohn's disease.

Authors: J R Korzenik; B K Dieckgraefe
Journal: Dig Dis Sci Date: 2000-06 Impact factor: 3.199

Review 2. Immunosuppressive drugs in inflammatory bowel disease. A review of their mechanisms of efficacy and place in therapy.

Authors: A B Hawthorne; C J Hawkey
Journal: Drugs Date: 1989-08 Impact factor: 9.546

Oral BCG vaccine in Crohn's disease.

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