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Literature DB >> 7058333

Histone proteins in HeLa S3 cells are synthesized in a cell cycle stage specific manner.

F Marashi, L Baumbach, R Rickles, F Sierra, J L Stein, G S Stein.

Abstract

The synthesis of histone proteins in G1 and S phase HeLa S3 cells was examined by two-dimensional electrophoretic fractionation of nuclear and total cellular proteins. Newly synthesized histones were detected only in S phase cells. Histone messenger RNA sequences, as detected by hybridization with cloned human histone genes, were present in the cytoplasm of S phase but not G1 cells.

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Mesh：

Substances：
Histones
Cytarabine

Year: 1982 PMID： 7058333 DOI： 10.1126/science.7058333

Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728

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Cited

14 in total

1. Targeting of a chimeric human histone fusion mRNA to membrane-bound polysomes in HeLa cells.

Authors: G Zambetti; J Stein; G Stein
Journal: Proc Natl Acad Sci U S A Date: 1987-05 Impact factor: 11.205

2. Altered binding of human histone gene transcription factors during the shutdown of proliferation and onset of differentiation in HL-60 cells.

Authors: G Stein; J Lian; J Stein; R Briggs; V Shalhoub; K Wright; U Pauli; A van Wijnen
Journal: Proc Natl Acad Sci U S A Date: 1989-03 Impact factor: 11.205

Histone proteins in HeLa S3 cells are synthesized in a cell cycle stage specific manner.

1. Targeting of a chimeric human histone fusion mRNA to membrane-bound polysomes in HeLa cells.

2. Altered binding of human histone gene transcription factors during the shutdown of proliferation and onset of differentiation in HL-60 cells.

3. A series of repetitive DNA sequences are associated with human core and H1 histone genes.

4. Coupling of histone mRNA levels to radioresistant DNA synthesis in ataxia-telangiectasia cells.

5. Biosynthesis and posttranslational acetylation of histones during spherulation of Physarum polycephalum.

6. Multiple, independently regulated, polyadenylated messages for histone H3 and H4 in Tetrahymena.

Review 7. The architectural organization of human stem cell cycle regulatory machinery.

8. Influence of DNA synthesis inhibition on the coordinate expression of core human histone genes during S phase.

9. Inhibition of protein synthesis stabilizes histone mRNA.

10. Coordinate regulation of multiple histone mRNAs during the cell cycle in HeLa cells.