Literature DB >> 3472231

Targeting of a chimeric human histone fusion mRNA to membrane-bound polysomes in HeLa cells.

G Zambetti, J Stein, G Stein.   

Abstract

The subcellular location of histone mRNA-containing polysomes may play a key role in the posttranscriptional events that mediate histone mRNA turnover following inhibition of DNA synthesis. Previously, it has been shown that histone mRNA is found primarily on free polysomes that are associated with the cytoskeleton. We report here the construction of an Escherichia coli pBR322 beta-lactamase signal peptide-human H3 histone fusion gene. The fusion transcript is targeted to membrane-bound polysomes and remains stable following interruption of DNA replication. Relocating mRNA within the cell may provide a procedure for studying the posttranscriptional regulation of gene expression.

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Year:  1987        PMID： 3472231      PMCID： PMC304722          DOI： 10.1073/pnas.84.9.2683

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  36 in total

1.  Hybridization analysis of histone messenger RNA: association with polyribosomes during the cell cycle.

Authors:  J L Stein; C L Thrall; W D Park; R J Mans; G S Stein
Journal:  Science       Date:  1975-08-15       Impact factor: 47.728

2.  Control of histone synthesis in HeLa cells.

Authors:  W B Butler; G C Mueller
Journal:  Biochim Biophys Acta       Date:  1973-02-04

3.  Rapidly labeled, polyribosome-associated RNA having the properties of histone messenger.

Authors:  T W Borun; M D Scharff; E Robbins
Journal:  Proc Natl Acad Sci U S A       Date:  1967-11       Impact factor: 11.205

4.  Requirement of protein synthesis for the coupling of histone mRNA levels and DNA replication.

Authors:  S Helms; L Baumbach; G Stein; J Stein
Journal:  FEBS Lett       Date:  1984-03-12       Impact factor: 4.124

5.  Eukaryotic signal sequence transports insulin antigen in Escherichia coli.

Authors:  K Talmadge; S Stahl; W Gilbert
Journal:  Proc Natl Acad Sci U S A       Date:  1980-06       Impact factor: 11.205

Review 6.  Compilation of published signal sequences.

Authors:  M E Watson
Journal:  Nucleic Acids Res       Date:  1984-07-11       Impact factor: 16.971

7.  Regulation of human histone gene expression: kinetics of accumulation and changes in the rate of synthesis and in the half-lives of individual histone mRNAs during the HeLa cell cycle.

Authors:  N Heintz; H L Sive; R G Roeder
Journal:  Mol Cell Biol       Date:  1983-04       Impact factor: 4.272

8.  Multiple H4 histone mRNAs of HeLa cells are encoded in different genes.

Authors:  A C Lichtler; F Sierra; S Clark; J R Wells; J L Stein; G S Stein
Journal:  Nature       Date:  1982-07-08       Impact factor: 49.962

9.  Coordinate regulation of multiple histone mRNAs during the cell cycle in HeLa cells.

Authors:  M Plumb; J Stein; G Stein
Journal:  Nucleic Acids Res       Date:  1983-04-25       Impact factor: 16.971

10.  Enhancer-facilitated expression of a human H4 histone gene.

Authors:  A Shiels; F Marashi; G Stein; J Stein
Journal:  Biochem Biophys Res Commun       Date:  1985-02-28       Impact factor: 3.575
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  16 in total

Review 1.  Growth regulation of human variant histone genes and acetylation of the encoded proteins.

Authors:  D Alvelo-Ceron; L Niu; D G Collart
Journal:  Mol Biol Rep       Date:  2000-06       Impact factor: 2.316

2.  "In situ" translation: use of the cytoskeletal framework to direct cell-free protein synthesis.

Authors:  D Biegel; J S Pachter
Journal:  In Vitro Cell Dev Biol       Date:  1991-01

3.  Competition between the signal sequence and a 3'UTR localisation signal during redirection of beta-globin mRNA to the endoplasmic reticulum: implications for biotechnology.

Authors:  K A Partridge; A Johannessen; A Tauler; I F Pryme; J E Hesketh
Journal:  Cytotechnology       Date:  1999-07       Impact factor: 2.058

4.  Developmental regulation of bicoid mRNA stability is mediated by the first 43 nucleotides of the 3' untranslated region.

Authors:  P Surdej; M Jacobs-Lorena
Journal:  Mol Cell Biol       Date:  1998-05       Impact factor: 4.272

5.  A 6-fold difference in the half-life of immunoglobulin mu heavy chain mRNA in cell lines representing two stages of B cell differentiation.

Authors:  A Cox; J S Emtage
Journal:  Nucleic Acids Res       Date:  1989-12-25       Impact factor: 16.971

Review 6.  Modifications in molecular mechanisms associated with control of cell cycle regulated human histone gene expression during differentiation.

Authors:  G S Stein; J L Stein; J B Lian; A J Van Wijnen; K L Wright; U Pauli
Journal:  Cell Biophys       Date:  1989-12

7.  Autogenous regulation of histone mRNA decay by histone proteins in a cell-free system.

Authors:  S W Peltz; J Ross
Journal:  Mol Cell Biol       Date:  1987-12       Impact factor: 4.272

Review 8.  mRNA stability in mammalian cells.

Authors:  J Ross
Journal:  Microbiol Rev       Date:  1995-09

9.  Specific endonucleolytic cleavages of mouse albumin mRNA and their modulation during liver development.

Authors:  S Tharun; R Sirdeshmukh
Journal:  Nucleic Acids Res       Date:  1995-02-25       Impact factor: 16.971

10.  An A + U-rich element RNA-binding factor regulates c-myc mRNA stability in vitro.

Authors:  G Brewer
Journal:  Mol Cell Biol       Date:  1991-05       Impact factor: 4.272
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