Literature DB >> 7057924

Primary structure of the human Met- and Leu-enkephalin precursor and its mRNA.

M Comb, P H Seeburg, J Adelman, L Eiden, E Herbert.   

Abstract

The nucleotide sequence of a complete cDNA copy of enkephalin precursor mRNA from human phaeochromocytoma is reported. The corresponding amino acid sequence shows that the precursor is 267 amino acids long and contains six interspersed Met-enkephalin sequences and one Leu-enkephalin sequence. Five of the seven enkephalins are flanked on both sides by pairs of basic amino acid residues. The precursors does not contain the sequences of the opioid peptides, dynorphin, alpha-neo-endorphin or beta-endorphin.

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Year:  1982        PMID： 7057924     DOI： 10.1038/295663a0

Source DB:  PubMed          Journal:  Nature        ISSN： 0028-0836            Impact factor:   49.962


  83 in total

1.  Striatal responses to partial dopaminergic lesion: evidence for compensatory sprouting.

Authors:  D D Song; S N Haber
Journal:  J Neurosci       Date:  2000-07-01       Impact factor: 6.167

2.  Stimulation of GABAB receptors increases the expression of the proenkephalin gene in slice cultures of rat neocortex.

Authors:  F Mörl; J Leemhuis; K Lindemeyer; N Grass; W Nörenberg; D K Meyer
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2003-05-06       Impact factor: 3.000

Review 3.  The Jeremiah Metzger Lecture. From POMC to functional diversity of neural peptides: the key importance of convertases.

Authors:  M Chretien; L Gasper; S Benjannet; M Mbikay; C Lazure; N G Seidah
Journal:  Trans Am Clin Climatol Assoc       Date:  1991

4.  Immunohistochemical localization of opioid peptides in the brain of the leech Theromyzon tessulatum.

Authors:  M Verger-Bocquet; J Malecha; G Tramu
Journal:  Cell Tissue Res       Date:  1987-10       Impact factor: 5.249

Review 5.  The lipophilic bullet hits the targets: medicinal chemistry of adamantane derivatives.

Authors:  Lukas Wanka; Khalid Iqbal; Peter R Schreiner
Journal:  Chem Rev       Date:  2013-02-25       Impact factor: 60.622

6.  Electroconvulsive shock increases preproenkephalin messenger RNA abundance in rat hypothalamus.

Authors:  K Yoshikawa; J S Hong; S L Sabol
Journal:  Proc Natl Acad Sci U S A       Date:  1985-01       Impact factor: 11.205

7.  Enkephalin convertase localization by [3H]guanidinoethylmercaptosuccinic acid autoradiography: selective association with enkephalin-containing neurons.

Authors:  D R Lynch; S M Strittmatter; S H Snyder
Journal:  Proc Natl Acad Sci U S A       Date:  1984-10       Impact factor: 11.205

8.  Proenkephalin, [Met]enkephalin, and oxytocin immunoreactivities are colocalized in bovine hypothalamic magnocellular neurons.

Authors:  J J Vanderhaeghen; F Lotstra; D R Liston; J Rossier
Journal:  Proc Natl Acad Sci U S A       Date:  1983-08       Impact factor: 11.205

9.  In vitro synthesis of thymosin beta 4 encoded by rat spleen mRNA.

Authors:  A W Filipowicz; B L Horecker
Journal:  Proc Natl Acad Sci U S A       Date:  1983-04       Impact factor: 11.205

10.  Carboxypeptidase B-like converting enzyme activity in secretory granules of rat pituitary.

Authors:  V Y Hook; Y P Loh
Journal:  Proc Natl Acad Sci U S A       Date:  1984-05       Impact factor: 11.205
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