| Literature DB >> 7053574 |
E J Stanbridge, C J Der, C J Doersen, R Y Nishimi, D M Peehl, B E Weissman, J E Wilkinson.
Abstract
Intraspecific human-human cell hybrids provide a stable model system with which to investigate the genetic control of transformed and tumorigenic phenotypes. Using this system it has been shown that these phenotypes are under separate genetic control. Furthermore, the tumorigenic phenotype can be complemented by fusion of different tumorigenic cells, resulting in nontumorigenic hybrids. This system also provides information on the control of differentiated function. Molecular cytogenetic techniques should reveal the nature of the chromosomal control of neoplastic transformation.Entities:
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Year: 1982 PMID： 7053574 DOI： 10.1126/science.7053574
Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728