Literature DB >> 7045689

A covalent adduct between the uracil ring and the active site of an aminoacyl tRNA synthetase.

R M Starzyk, S W Koontz, P Schimmel.   

Abstract

A covalent adduct of an aminoacyl tRNA synthetase and uracil nucleoside has been isolated. The enzyme adduct is catalytically inactive; one nucleoside is bound per catalytic site. The release of uridine restores enzyme activity. The nucleoside attaches to a protein segment required for tRNA interaction. The findings add support to concepts of a covalent component for some protein-nucleic acid complexes.

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Year:  1982        PMID： 7045689     DOI： 10.1038/298136a0

Source DB:  PubMed          Journal:  Nature        ISSN： 0028-0836            Impact factor:   49.962


  18 in total

1.  Use of synthetic oligoribonucleotides to probe RNA-protein interactions in the MS2 translational operator complex.

Authors:  S J Talbot; S Goodman; S R Bates; C W Fishwick; P G Stockley
Journal:  Nucleic Acids Res       Date:  1990-06-25       Impact factor: 16.971

2.  Oxidation-reduction sensitive interaction of a cellular 50-kDa protein with an RNA hairpin in the 5' noncoding region of the poliovirus genome.

Authors:  L Najita; P Sarnow
Journal:  Proc Natl Acad Sci U S A       Date:  1990-08       Impact factor: 11.205

3.  The nucleotide sequence of Scenedesmus obliquus chloroplast elongator methionine-accepting tRNA.

Authors:  J M McCoy; N M Keene; D S Jones
Journal:  Biochem J       Date:  1986-08-15       Impact factor: 3.857

4.  An RNA mutation that increases the affinity of an RNA-protein interaction.

Authors:  P T Lowary; O C Uhlenbeck
Journal:  Nucleic Acids Res       Date:  1987-12-23       Impact factor: 16.971

5.  Using in vitro selection to direct the covalent attachment of human immunodeficiency virus type 1 Rev protein to high-affinity RNA ligands.

Authors:  K B Jensen; B L Atkinson; M C Willis; T H Koch; L Gold
Journal:  Proc Natl Acad Sci U S A       Date:  1995-12-19       Impact factor: 11.205

6.  Covalent enzyme-RNA complex: a tRNA modification that prevents a covalent enzyme interaction also prevents aminoacylation.

Authors:  R Starzyk; H Schoemaker; P Schimmel
Journal:  Proc Natl Acad Sci U S A       Date:  1985-01       Impact factor: 11.205

7.  In vitro selection of an RNA sequence that interacts with high affinity with thymidylate synthase.

Authors:  X Lin; N Mizunuma; T Chen; S M Copur; G F Maley; J Liu; F Maley; E Chu
Journal:  Nucleic Acids Res       Date:  2000-11-01       Impact factor: 16.971

8.  Identification of critical amino acid residues on human dihydrofolate reductase protein that mediate RNA recognition.

Authors:  Ningwen Tai; Yuyan Ding; John C Schmitz; Edward Chu
Journal:  Nucleic Acids Res       Date:  2002-10-15       Impact factor: 16.971

9.  Functional communication in the recognition of tRNA by Escherichia coli glutaminyl-tRNA synthetase.

Authors:  M J Rogers; T Adachi; H Inokuchi; D Söll
Journal:  Proc Natl Acad Sci U S A       Date:  1994-01-04       Impact factor: 11.205

10.  Critical chemical features in trans-acting-responsive RNA are required for interaction with human immunodeficiency virus type 1 Tat protein.

Authors:  M Sumner-Smith; S Roy; R Barnett; L S Reid; R Kuperman; U Delling; N Sonenberg
Journal:  J Virol       Date:  1991-10       Impact factor: 5.103
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