| Literature DB >> 7045086 |
M C Cone, K Marchitto, B Zehfus, A J Ferro.
Abstract
Cells of the yeast Saccharomyces cerevisiae are normally impermeable to the purine nucleosides adenosine and 5'-deoxy-5'-methylthioadenosine (MTA), a product of polyamine biosynthesis. cordycepin-sensitive, adenosine-utilizing strains of S. cerevisiae were able to use MTA to fulfill an auxotrophic requirement for purine. Cordycepin-sensitive strains carrying a met5 mutation were also able to use MTA as a source of methionine. These MTA-utilizing strains of S. cerevisiae should be useful for metabolic studies of the fate of MTA.Entities:
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Year: 1982 PMID: 7045086 PMCID: PMC220274 DOI: 10.1128/jb.151.1.510-515.1982
Source DB: PubMed Journal: J Bacteriol ISSN: 0021-9193 Impact factor: 3.490