Literature DB >> 704360

Distribution of 7-methylguanine and of replication sites in the different kinetic classes of DNA from rats treated with dimethylnitrosamine.

A I Galbraith, M R Chapleo, R F Itzhaki.   

Abstract

The distribution of 7-methylguanine in the families of repetitive and unique sequences of rat liver chromatin DNA has been studied using the technique of DNA-DNA reassociation. Rats were injected with di[14C]methylnitrosamine and chromatin DNA was prepared 3 h later. The distribution of 7-methylguanine was found to be random between these classes of DNA. We have also studied chromatin DNA from rats treated with unlabelled DMN plus [3H]thymidine in this way, in order to find if DMN affects DNA synthesis within any one kinetic class. Our results suggest that there is no difference in the extent of synthesis between these classes.

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Year:  1978        PMID： 704360      PMCID： PMC342255          DOI： 10.1093/nar/5.9.3357

Source DB:  PubMed          Journal:  Nucleic Acids Res        ISSN： 0305-1048            Impact factor:   16.971


  18 in total

1.  A MICRO-BIURET METHOD FOR ESTIMATING PROTEINS.

Authors:  R F ITZHAKI; D M GILL
Journal:  Anal Biochem       Date:  1964-12       Impact factor: 3.365

2.  The precision of ultraviolet absorption measurements in the Schmidt-Thannhauser procedure for nucleic acid estimation.

Authors:  A FLECK; H N MUNRO
Journal:  Biochim Biophys Acta       Date:  1962-05-14

3.  Distribution of covalently bound benzo(a)pyrene in chromatin.

Authors:  C L Jahn; G W Litman
Journal:  Biochem Biophys Res Commun       Date:  1976-05-23       Impact factor: 3.575

4.  Nonuniform distribution of DNA repair in chromatin after treatment with methyl methanesulfonate.

Authors:  W J Bodell
Journal:  Nucleic Acids Res       Date:  1977-08       Impact factor: 16.971

5.  Protein measurement with the Folin phenol reagent.

Authors:  O H LOWRY; N J ROSEBROUGH; A L FARR; R J RANDALL
Journal:  J Biol Chem       Date:  1951-11       Impact factor: 5.157

6.  Repair replication of DNA in the intact animal following treatment with dimethylnitrosamine and with methyl methanesulphonate, studied by fractionation of nuclei in a zonal centrifuge.

Authors:  V M Craddock; A R Henderson; C M Ansley
Journal:  Biochim Biophys Acta       Date:  1976-09-20

Review 7.  Formation and metabolism of alkylated nucleosides: possible role in carcinogenesis by nitroso compounds and alkylating agents.

Authors:  A E Pegg
Journal:  Adv Cancer Res       Date:  1977       Impact factor: 6.242

8.  Non-random binding of a chemical carcinogen to the DNA in chromatin.

Authors:  G Metzger; F X Wilhelm; M L Wilhelm
Journal:  Biochem Biophys Res Commun       Date:  1977-04-11       Impact factor: 3.575

9.  Distribution along DNA of the bound carcinogen N-acetoxy-N-2-acetylaminofluorene in chromatin modified in vitro.

Authors:  G Metzger; F X Wilhelm; M L Wilhelm
Journal:  Chem Biol Interact       Date:  1976-11       Impact factor: 5.192

10.  Reduced DNA repair in mouse satellite DNA after treatment with methylmethanesulfonate, and N-methyl-N-nitrosourea.

Authors:  W J Bodell; M R Banerjee
Journal:  Nucleic Acids Res       Date:  1976-07       Impact factor: 16.971
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  2 in total

1.  The use of radioimmunoassay to study the formation and disappearance of O6-methylguanine in mouse liver satellite and main-band DNA following dimethylnitrosamine administration.

Authors:  S A Kyrtopoulos; P F Swann
Journal:  J Cancer Res Clin Oncol       Date:  1980       Impact factor: 4.553

2.  Hydrogen bond catalysis of mononucleotide ethylation supports non-random DNA alkylations by N-ethyl, N-nitrosourea.

Authors:  K W Stahl; F E Köster
Journal:  Experientia       Date:  1984-07-15
  2 in total

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