Literature DB >> 7041569

Neutropenia induced by platelet-activating factor (PAF-acether) released from neutrophils: the inhibitory effect of prostacyclin (PGI2).

G Camussi, C Tetta, G Segoloni, M Chiara Deregibus, F Bussolino.   

Abstract

Soluble and phagocytic stimuli released PAF-acether from PMN leucocytes, as determined by chromatography and bioassay by platelet aggregation. The same material caused aggregation of human and rabbit PMN leucocytes in vitro which was inhibited by ETYA and PGI2. PGI2 also inhibited PAF-acether release by PMN leucocytes and, in vivo, PGI2 abolished not only PAF-acether-induced, but also immune complex or C5a-induced thrombocytopenia and neutropenia in rabbits. These data suggest that PAF-acether may be involved in activation of both platelets and PMN leucocytes in vivo.

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Year:  1981        PMID： 7041569     DOI： 10.1007/bf01978735

Source DB:  PubMed          Journal:  Agents Actions        ISSN： 0065-4299


  21 in total

1.  Activation of rabbit platelets by platelet-activating factor derived from IgE-sensitized basophils. Characteristics of the aggregation and its dissociation from secretion.

Authors:  P M Henson
Journal:  J Clin Invest       Date:  1977-08       Impact factor: 14.808

2.  Structural analysis of purified platelet-activating factor by lipases.

Authors:  J Benveniste; J P Le Couedic; J Polonsky; M Tence
Journal:  Nature       Date:  1977-09-08       Impact factor: 49.962

3.  The release of a platelet-activating factor by stimulated rabbit neutrophils.

Authors:  J M Lynch; G Z Lotner; S J Betz; P M Henson
Journal:  J Immunol       Date:  1979-09       Impact factor: 5.422

4.  The role of PMN-leucocyte lysosomes in tissue injury, inflammation and hypersensitivity. VI. The participation of the PMN-leucocyte and the blood platelet in systemic aggregate anaphylaxis.

Authors:  H Z Movat; T Uriuhara; N S Taichman; H C Rowsell; J F Mustard
Journal:  Immunology       Date:  1968-05       Impact factor: 7.397

5.  Pathobiology of the intravenous infusion of acetyl glyceryl ether phosphorylcholine (AGEPC), a synthetic platelet-activating factor (PAF), in the rabbit.

Authors:  L M McManus; D J Hanahan; C A Demopoulos; R N Pinckard
Journal:  J Immunol       Date:  1980-06       Impact factor: 5.422

6.  Mediators of immune complex-induced aggregation of polymorphonuclear neutrophils. I. C5a anaphylatoxin, neutrophil cationic proteins and their cleavage fragments.

Authors:  G Camussi; C Tetta; F Bussolino; F C Cappio; R Coda; C Masera; G Segoloni
Journal:  Int Arch Allergy Appl Immunol       Date:  1980

7.  The binding of platelet-activating factor (PAF) to polymorphonuclear neutrophils (PMN) as a trigger for the immune-induced PMN aggregation.

Authors:  G Camussi; F Bussolino; C Tetta; R Brusca; R Ragni
Journal:  Panminerva Med       Date:  1980 Jan-Mar 22       Impact factor: 5.197

8.  Platelet activating factor (PAF-acether): total synthesis of 1-O-octadecyl 2-O-acetyl sn-glycero-3-phosphoryl choline.

Authors:  J J Godfroid; F Heymans; E Michel; C Redeuilh; E Steiner; J Benveniste
Journal:  FEBS Lett       Date:  1980-07-28       Impact factor: 4.124

9.  Platelet-activating factor. Evidence for 1-O-alkyl-2-acetyl-sn-glyceryl-3-phosphorylcholine as the active component (a new class of lipid chemical mediators).

Authors:  C A Demopoulos; R N Pinckard; D J Hanahan
Journal:  J Biol Chem       Date:  1979-10-10       Impact factor: 5.157

10.  Neutrophil aggregation and degranulation. Effect of arachidonic acid.

Authors:  J T O'Flaherty; H J Showell; E L Becker; P A Ward
Journal:  Am J Pathol       Date:  1979-05       Impact factor: 4.307
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  6 in total

Review 1.  Biology and biochemistry of platelet-activating factor.

Authors:  J T O'Flaherty; R L Wykle
Journal:  Clin Rev Allergy       Date:  1983-09

2.  Inflammatory mediators released by complement-derived peptides.

Authors:  H Bult; A G Herman
Journal:  Agents Actions       Date:  1983-08

3.  Evidence for the role of platelet-activating factor in immune complex vasculitis in the rat.

Authors:  J S Warren; D M Mandel; K J Johnson; P A Ward
Journal:  J Clin Invest       Date:  1989-02       Impact factor: 14.808

4.  Vasodilatation and inhibition of mediator release represent two distinct mechanisms for prostaglandin modulation of acute mast cell-dependent inflammation.

Authors:  J Raud
Journal:  Br J Pharmacol       Date:  1990-03       Impact factor: 8.739

5.  Polymorphonuclear leukocyte-dependent plasma leakage in the rabbit skin is enhanced or inhibited by prostacyclin, depending on the route of administration.

Authors:  M Rampart; T J Williams
Journal:  Am J Pathol       Date:  1986-07       Impact factor: 4.307

6.  Hypotensive action of IgG preparations containing aggregates is suppressed by PAF-receptor antagonist BN 52021 and by gadolinium chloride (an agent blocking Kupffer cell function).

Authors:  B Jenei; G Lázár; K Bartha; G A Medgyesi
Journal:  Agents Actions       Date:  1991-03
  6 in total

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