Literature DB >> 7041073

Serum penicillin concentrations after intramuscular administration of benzathine penicillin G in children.

C M Ginsburg, G H McCracken, T C Zweighaft.   

Abstract

Concentrations of penicillin were measured in serum samples of 26 children who received benzathine penicillin G (BPG) alone or in combination with procaine penicillin (PBPG). Both preparations were well absorbed; peak concentrations of penicillin after PBPG administration were 25-fold larger than those after BPG. One third and one half of serum samples from BPG and PBPG patients, respectively, contained no measurable penicillin activity at 18 days. At 30 days, there was no penicillin activity in any of the samples. These data raise questions regarding the use of BPG and PBPG for prophylaxis of group A streptococcal and pneumococcal infections.

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Year:  1982        PMID： 7041073

Source DB:  PubMed          Journal:  Pediatrics        ISSN： 0031-4005            Impact factor:   7.124


  6 in total

Review 1.  Principles of drug biodisposition in the neonate. A critical evaluation of the pharmacokinetic-pharmacodynamic interface (Part II).

Authors:  J B Besunder; M D Reed; J L Blumer
Journal:  Clin Pharmacokinet       Date:  1988-05       Impact factor: 6.447

2.  Prevention of pneumococcal infection in children with homozygous sickle cell disease.

Authors:  A B John; A Ramlal; H Jackson; G H Maude; A W Sharma; G R Serjeant
Journal:  Br Med J (Clin Res Ed)       Date:  1984-05-26

3.  Benzathine penicillin G for rheumatic fever prophylaxis: 2-weekly versus 4-weekly regimens.

Authors:  A S Kassem; A A Madkour; B Z Massoud; S R Zaher
Journal:  Indian J Pediatr       Date:  1992 Nov-Dec       Impact factor: 1.967

Review 4.  Prophylactic antibiotics for preventing pneumococcal infection in children with sickle cell disease.

Authors:  Angela E Rankine-Mullings; Shirley Owusu-Ofori
Journal:  Cochrane Database Syst Rev       Date:  2017-10-10

5.  Penicillin concentrations after increased doses of benzathine penicillin G for prevention of secondary rheumatic fever.

Authors:  B J Currie; T Burt; E L Kaplan
Journal:  Antimicrob Agents Chemother       Date:  1994-05       Impact factor: 5.191

6.  Prophylactic antibiotics for preventing pneumococcal infection in children with sickle cell disease.

Authors:  Angela E Rankine-Mullings; Shirley Owusu-Ofori
Journal:  Cochrane Database Syst Rev       Date:  2021-03-08
  6 in total

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