Literature DB >> 7035030

Induction of delayed-type hypersensitivity to Mycobacterium leprae in healthy individuals.

A H Smelt, R J Rees, F Y Liew.   

Abstract

Delayed-type hypersensitivity (DTH) to a soluble Mycobacterium leprae skin test antigen (SML) was successfully induced in healthy volunteers following immunization with 2 X 10(8) killed armadillo-derived M. leprae. No better sensitization was obtained by a mixture of live BCG and killed M. leprae. The relative specificity of the DTH reaction to SML has been demonstrated in this study, since little cross-reactivity was observed to PPD, after immunization with BCG ro M, leprae alone, or combined. Moreover, armadillo-derived M. leprae readily induced a specific hypersensitivity with the time course DTH response associated with protective immunity suggesting that this bacterial preparation may be a candidate for an effective anti-leprosy vaccine.

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Year:  1981        PMID： 7035030      PMCID： PMC1537322     

Source DB:  PubMed          Journal:  Clin Exp Immunol        ISSN： 0009-9104            Impact factor:   4.330


  16 in total

Review 1.  The immunology of antituberculous immunity.

Authors:  G B Mackaness
Journal:  Am Rev Respir Dis       Date:  1968-03

Review 2.  Relation between delayed hypersensitivity and immunity in tuberculosis.

Authors:  G P Youmans
Journal:  Am Rev Respir Dis       Date:  1975-02

3.  Studies on the antigenic specificity of Mycobacterium leprae. I. Demonstration of soluble antigens in leprosy nodules by immunodiffusion.

Authors:  M Abe
Journal:  Int J Lepr Other Mycobact Dis       Date:  1970 Apr-Jun

4.  Characterization of the cellular immune defect in lepromatous leprosy: a specific lack of circulating Mycobacterium leprae-reactive lymphocytes.

Authors:  T Godal; B Myklestad; D R Samuel; B Myrvang
Journal:  Clin Exp Immunol       Date:  1971-12       Impact factor: 4.330

5.  Specific and nonspecific resistance in mice immunized with irradiated Myobacterium leprae.

Authors:  P J Patel; M J Lefford
Journal:  Infect Immun       Date:  1978-06       Impact factor: 3.441

6.  Lymphocyte transformation test in leprosy; correlation of the response with inflammation of lesions.

Authors:  G Bjune; R S Barnetson; D S Ridley; G Kronvall
Journal:  Clin Exp Immunol       Date:  1976-07       Impact factor: 4.330

7.  Antibody response in rabbits to immunization with Mycobacterium leprae.

Authors:  M Harboe; O Closs; B Bjorvatn; G Kronvall; N H Axelsen
Journal:  Infect Immun       Date:  1977-12       Impact factor: 3.441

8.  Induction of cell-mediated immunity to Mycobacterium leprae in mice.

Authors:  P J Patel; M J Lefford
Journal:  Infect Immun       Date:  1978-01       Impact factor: 3.441

9.  The spectrum of human tuberculosis.

Authors:  L Lenzini; P Rottoli; L Rottoli
Journal:  Clin Exp Immunol       Date:  1977-02       Impact factor: 4.330

10.  Mycobacterium leprae specific antibodies detected by radioimmunoassay.

Authors:  M Harboe; O Closs; G Bjune; G Kronvall; N H Axelsen
Journal:  Scand J Immunol       Date:  1978       Impact factor: 3.487
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  10 in total

1.  Defective intralesional interferon-gamma activity in patients with lepromatous leprosy.

Authors:  B Volc-Platzer; H Stemberger; T Luger; T Radaszkiewicz; G Wiedermann
Journal:  Clin Exp Immunol       Date:  1988-02       Impact factor: 4.330

2.  Immunological activity of a 14-kilodalton recombinant protein of Mycobacterium tuberculosis H37Rv.

Authors:  A E Kingston; P R Salgame; N A Mitchison; M J Colston
Journal:  Infect Immun       Date:  1987-12       Impact factor: 3.441

3.  Failure of Mycobacterium leprae soluble antigens to suppress delayed-type hypersensitivity reaction to tuberculin.

Authors:  P E Fine; P J Gruer; N Maine; J M Ponnighaus; R J Rees; J L Stanford
Journal:  Clin Exp Immunol       Date:  1989-08       Impact factor: 4.330

4.  Phenolic glycolipid 1 of Mycobacterium leprae causes nonspecific inflammation but has no effect on cell-mediated responses in mice.

Authors:  S J Brett; C Lowe; S N Payne; P Draper
Journal:  Infect Immun       Date:  1984-12       Impact factor: 3.441

5.  Induction of delayed-type hypersensitivity in human volunteers immunized with a candidate leprosy vaccine consisting of killed Mycobacterium leprae.

Authors:  H K Gill; A S Mustafa; T Godal
Journal:  Bull World Health Organ       Date:  1986       Impact factor: 9.408

6.  Suppression of delayed hypersensitivity skin reactions to tuberculin by M. leprae antigens in patients with lepromatous and tuberculoid leprosy.

Authors:  U Sengupta; S Sinha; G Ramu; J Lamb; J Ivanyi
Journal:  Clin Exp Immunol       Date:  1987-04       Impact factor: 4.330

7.  Limiting dilution analysis of the human T cell response to mycobacterial antigens from BCG vaccinated individuals and leprosy patients.

Authors:  S J Brett; A E Kingston; M J Colston
Journal:  Clin Exp Immunol       Date:  1987-06       Impact factor: 4.330

8.  Adoptive cell transfer of resistance to Mycobacterium leprae infections in mice.

Authors:  C Lowe; S J Brett; R J Rees
Journal:  Clin Exp Immunol       Date:  1985-08       Impact factor: 4.330

9.  Failure to induce delayed-type hypersensitivity to Mycobacterium leprae in long-term treated lepromatous leprosy patients.

Authors:  A H Smelt; R H Rees; F Y Liew
Journal:  Clin Exp Immunol       Date:  1981-06       Impact factor: 4.330

10.  Safety and efficacy assessment of two new leprosy skin test antigens: randomized double blind clinical study.

Authors:  Becky L Rivoire; Nathan A Groathouse; Stephen TerLouw; Kapil Dev Neupane; Chaman Ranjit; Bishwa Raj Sapkota; Saraswoti Khadge; Chhatra B Kunwar; Chatra B Kunwar; Murdo Macdonald; Rachel Hawksworth; Min B Thapa; Deanna A Hagge; Melinda Tibbals; Carol Smith; Tina Dube; Dewei She; Mark Wolff; Eric Zhou; Mamodikoe Makhene; Robin Mason; Christine Sizemore; Patrick J Brennan
Journal:  PLoS Negl Trop Dis       Date:  2014-05-29
  10 in total

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