Literature DB >> 7035031

Failure to induce delayed-type hypersensitivity to Mycobacterium leprae in long-term treated lepromatous leprosy patients.

A H Smelt, R H Rees, F Y Liew.   

Abstract

Lepromatous leprosy (LL) patients whose bacillary load has decreased to almost undetectable levels by long-term chemotherapy failed to develop delayed-type hypersensitivity (DTH) to Mycobacterium leprae antigen following immunization with killed armadillo-derived M. leprae. When these LL patients were immunization with killed armadillo-derived M. leprae. When these LL patients were immunized with killed M. leprae in a mixture with live BCG, only DTH to purified protein derivative (PPD) was induced. These results are further evidence that immunological unresponsiveness to the leprosy antigen of patients with lepromatous leprosy is antigen-specific and non-reversible.

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Year:  1981        PMID： 7035031      PMCID： PMC1537307     

Source DB:  PubMed          Journal:  Clin Exp Immunol        ISSN： 0009-9104            Impact factor:   4.330


  20 in total

1.  Quantitative dinitrochlorobenzene (DNCB) responsivity and phytohemagglutinin (PHA) induced lymphocyte transformation in patients with lepromatous leprosy.

Authors:  T H Rea; F Quismorio; B Harding; G Friou; N Levan
Journal:  Int J Lepr Other Mycobact Dis       Date:  1976 Jan-Jun

2.  Ten years of dapsone in lepromatous leprosy: clinical, bacteriological and histological assessment and the finding of viable leprosy bacilli.

Authors:  M F Waters; R J Rees; A C McDougall; A G Weddell
Journal:  Lepr Rev       Date:  1974-12       Impact factor: 0.537

3.  HL-A antigens in leprosy.

Authors:  M Kreisler; A Arnaiz; B Perez; E Fernandez Cruz; A Bootello
Journal:  Tissue Antigens       Date:  1974

4.  Influence of chemotherapy and serum factors on the mitogenic response of peripheral leucocytes of leprosy patients to phytohaemagglutinin.

Authors:  V L Mehra; G P Talwar; K Balakrishnan; L K Bhutani
Journal:  Clin Exp Immunol       Date:  1972-10       Impact factor: 4.330

5.  HL-A antigens and susceptibility to diseases. II. Leprosy.

Authors:  E Thorsby; T Godal; B Myrvang
Journal:  Tissue Antigens       Date:  1973

6.  Leprosy and genetics. A review of past research with remarks concerning future investigations.

Authors:  B Beiguelman
Journal:  Bull World Health Organ       Date:  1967       Impact factor: 9.408

7.  Experimental murine leprosy: growth of Mycobacterium lepraemurium in C3H and C57/BL mice after footpad inoculation.

Authors:  O Closs
Journal:  Infect Immun       Date:  1975-09       Impact factor: 3.441

8.  Characterization of the cellular immune defect in lepromatous leprosy: a specific lack of circulating Mycobacterium leprae-reactive lymphocytes.

Authors:  T Godal; B Myklestad; D R Samuel; B Myrvang
Journal:  Clin Exp Immunol       Date:  1971-12       Impact factor: 4.330

9.  Histocompatibility antigens (HL-A) in leprosy.

Authors:  A Dasgupta; N K Mehra; S K Ghei; M C Vaidya
Journal:  Tissue Antigens       Date:  1975-04

10.  Histocompatibility antigens in leprosy.

Authors:  G S Smith; R L Walford; C C Shepard; R Payne; G J Prochazka
Journal:  Vox Sang       Date:  1975       Impact factor: 2.144
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  2 in total

1.  Defective intralesional interferon-gamma activity in patients with lepromatous leprosy.

Authors:  B Volc-Platzer; H Stemberger; T Luger; T Radaszkiewicz; G Wiedermann
Journal:  Clin Exp Immunol       Date:  1988-02       Impact factor: 4.330

2.  Evidence that the Mitsuda reaction to Mycobacterium leprae can be mediated by lymphocytes responsive to Mycobacterium tuberculosis.

Authors:  P P Roberts; H M Dockrell; K P McAdam
Journal:  Clin Exp Immunol       Date:  1988-06       Impact factor: 4.330
  2 in total

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