Literature DB >> 7027441

Hemin lyses malaria parasites.

A U Orjih, H S Banyal, R Chevli, C D Fitch.   

Abstract

Malaria parasites isolated from mouse erythrocytes are lysed by ferriprotoporphyrin IX chloride (hemin) or by a chloroquine-hemin complex in amounts that could be produced by release of less than 0.1 percent of the heme in erythrocytic hemoglobin. This effect of hemin may explain the protection against malaria provided by thalassemia and other conditions causing intracellular denaturation of hemoglobin. The toxicity of the chloroquine-hemin complex may explain the selective antimalarial action of chloroquine.

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Year:  1981        PMID： 7027441     DOI： 10.1126/science.7027441

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  30 in total

1.  Mechanism of malarial haem detoxification inhibition by chloroquine.

Authors:  A V Pandey; H Bisht; V K Babbarwal; J Srivastava; K C Pandey; V S Chauhan
Journal:  Biochem J       Date:  2001-04-15       Impact factor: 3.857

2.  Computational studies of new potential antimalarial compounds--stereoelectronic complementarity with the receptor.

Authors:  César Portela; Carlos M M Afonso; Madalena M M Pinto; Maria João Ramos
Journal:  J Comput Aided Mol Des       Date:  2003-09       Impact factor: 3.686

3.  2-tert-butyl-8-quinolinamines exhibit potent blood schizontocidal antimalarial activity via inhibition of heme crystallization.

Authors:  Nguyen Tien Huy; Keisuke Mizunuma; Kirandeep Kaur; Nguyen Thanh Thuy Nhien; Meenakshi Jain; Dinh Thanh Uyen; Shigeharu Harada; Rahul Jain; Kaeko Kamei
Journal:  Antimicrob Agents Chemother       Date:  2007-06-11       Impact factor: 5.191

4.  Silencing of maternal heme-binding protein causes embryonic mitochondrial dysfunction and impairs embryogenesis in the blood sucking insect Rhodnius prolixus.

Authors:  Ana Beatriz Walter-Nuno; Matheus P Oliveira; Marcus F Oliveira; Renata L Gonçalves; Isabela B Ramos; Leonardo B Koerich; Pedro L Oliveira; Gabriela O Paiva-Silva
Journal:  J Biol Chem       Date:  2013-08-28       Impact factor: 5.157

5.  Quinolines block every step of malaria heme crystal growth.

Authors:  David J Sullivan
Journal:  Proc Natl Acad Sci U S A       Date:  2017-07-10       Impact factor: 11.205

6.  Antimalarials inhibit hematin crystallization by unique drug-surface site interactions.

Authors:  Katy N Olafson; Tam Q Nguyen; Jeffrey D Rimer; Peter G Vekilov
Journal:  Proc Natl Acad Sci U S A       Date:  2017-05-30       Impact factor: 11.205

Review 7.  Involvement of heme in the antimalarial action of chloroquine.

Authors:  C D Fitch
Journal:  Trans Am Clin Climatol Assoc       Date:  1998

8.  Ligands of the peripheral benzodiazepine receptor are potent inhibitors of Plasmodium falciparum and Toxoplasma gondii in vitro.

Authors:  Florence Dzierszinski; Alexandra Coppin; Marlene Mortuaire; Etienne Dewailly; Christian Slomianny; Jean-Claude Ameisen; Frederic DeBels; Stanislas Tomavo
Journal:  Antimicrob Agents Chemother       Date:  2002-10       Impact factor: 5.191

9.  Lysis of Plasmodium falciparum by ferriprotoporphyrin IX and a chloroquine-ferriprotoporphyrin IX complex.

Authors:  C D Fitch; R Chevli; H S Banyal; G Phillips; M A Pfaller; D J Krogstad
Journal:  Antimicrob Agents Chemother       Date:  1982-05       Impact factor: 5.191

10.  False susceptibility of enterococci to aminoglycosides with blood-enriched Mueller-Hinton agar for disk susceptibility testing.

Authors:  R D Jenkins; S L Stevens; J M Craythorn; T W Thomas; M E Guinan; J M Matsen
Journal:  J Clin Microbiol       Date:  1985-09       Impact factor: 5.948
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