Literature DB >> 7025750

Effect of antimicrobial agents on human polymorphonuclear leukocyte microbicidal function.

W D Welch, D Davis, L D Thrupp.   

Abstract

The effect of 19 antimicrobial agents on human polymorphonuclear leukocyte function was evaluated by chemiluminescence assays, yeast phagocytosis and killing, and lactate dehydrogenase release. Tetracycline and trimethoprim inhibited chemiluminescence and reduced killing at therapeutic concentrations of 2 microgram/ml. Cephalothin inhibited yeast killing at a concentration of 20 microgram/ml, but a significant depression of polymorphonuclear leukocyte chemiluminescence was encountered only at higher levels of 200 microgram/ml. The inhibition shown by these drugs was reversible. None of the other antimicrobial agents tested demonstrated inhibition of chemiluminescence, phagocytosis, or killing at usual clinical serum levels. No antimicrobial agent tested caused release of lactate dehydrogenase from polymorphonuclear leukocytes. The results suggest that therapeutic concentrations of tetracycline, trimethoprim, and cephalothin may inhibit optimal polymorphonuclear leukocyte microbicidal function.

Entities:  

Mesh：

Substances：

Year:  1981        PMID： 7025750      PMCID： PMC181624          DOI： 10.1128/AAC.20.1.15

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  17 in total

1.  Antimicrobial mechanisms in neutrophilic polymorphonuclear leukocytes.

Authors:  S J Klebanoff
Journal:  Semin Hematol       Date:  1975-04       Impact factor: 3.851

2.  Inhibition of phagocytotic metabolic changes of leukocytes by an intracellular calcium-antagonist 8-(N,N-diethylamino)-octyl-3,4,5-trimethoxybenzoate.

Authors:  T Matsumoto; K Takeshige; S Minakami
Journal:  Biochem Biophys Res Commun       Date:  1979-06-13       Impact factor: 3.575

3.  Tetracyclines and host defence mechanisms. Doxycycline interference with phagocytosis of Escherichia coli.

Authors:  H Gnarpe; D Leslie
Journal:  Microbios       Date:  1974 Jun-Jul

4.  Effect of tetracycline on the phagocytic function of human leukocytes.

Authors:  A Forsgren; D Schmeling; P G Quie
Journal:  J Infect Dis       Date:  1974-10       Impact factor: 5.226

5.  Effect of tetracycline, polymyxin B, and rifampin on phagocytosis.

Authors:  P D Hoeprich; C H Martin
Journal:  Clin Pharmacol Ther       Date:  1970 May-Jun       Impact factor: 6.875

6.  False-negative N.B.T. tests due to transient malfunction of neutrophils.

Authors:  A Rubinstein; B Pelet
Journal:  Lancet       Date:  1973-02-17       Impact factor: 79.321

7.  The uptake and localization of tetracycline in human blood cells.

Authors:  J K Park; R C Dow
Journal:  Br J Exp Pathol       Date:  1970-04

8.  A rapid, inexpensive and easily quantified assay for phagocytosis and microbicidal activity of macrophages and neutrophils.

Authors:  D W Simpson; R Roth; L D Loose
Journal:  J Immunol Methods       Date:  1979       Impact factor: 2.303

9.  Action of cefoxitin and cefamandole on human neutrophil function.

Authors:  J A Majeski; M J Morris; J W Alexander
Journal:  J Antibiot (Tokyo)       Date:  1978-10       Impact factor: 2.649

10.  Chemiluminescence of phagocytic cells caused by N-formylmethionyl peptides.

Authors:  G E Hatch; D E Gardner; D B Menzel
Journal:  J Exp Med       Date:  1978-01-01       Impact factor: 14.307
View more
  21 in total

1.  Antibacterial and immunostimulatory properties of chemotactic N-formyl peptide conjugates of ampicillin and amoxicillin.

Authors:  B W Bycroft; P M Lockey; A Penrose; R J Grout; P Williams
Journal:  Antimicrob Agents Chemother       Date:  1989-09       Impact factor: 5.191

2.  In vitro effect of cefodizime, imipenem/cilastatin and co-trimoxazole on dexamethasone and cyclosporin A depressed phagocytosis.

Authors:  A Dhondt; R Vanholder; M A Waterloos; G Glorieux; R De Smet; S Ringoir
Journal:  Infection       Date:  1998 Mar-Apr       Impact factor: 3.553

3.  Influence of antibiotics on formylmethionyl-leucyl-phenylalanine-induced leukocyte chemiluminescence.

Authors:  G Briheim; C Dahlgren
Journal:  Antimicrob Agents Chemother       Date:  1987-05       Impact factor: 5.191

4.  Influence of six antifungal agents on the chemiluminescence response of mouse spleen cells.

Authors:  G K Abruzzo; D M Giltinan; T P Capizzi; R A Fromtling
Journal:  Antimicrob Agents Chemother       Date:  1986-04       Impact factor: 5.191

5.  Design and analysis considerations in evaluating the chemiluminescence response of mouse spleen cells.

Authors:  D M Giltinan; T P Capizzi; G K Abruzzo; R A Fromtling
Journal:  J Clin Microbiol       Date:  1986-03       Impact factor: 5.948

6.  Interaction of beta-lactam antibiotics with the bactericidal activity of leukocytes against Escherichia coli.

Authors:  A Dalhoff
Journal:  Med Microbiol Immunol       Date:  1986       Impact factor: 3.402

7.  Influence of tetracyclines on human polymorphonuclear leukocyte function.

Authors:  J Glette; S Sandberg; G Hopen; C O Solberg
Journal:  Antimicrob Agents Chemother       Date:  1984-03       Impact factor: 5.191

8.  Phagocytic function and antibody-dependent cellular cytotoxicity of human neutrophils in the presence of N-formimidoyl thienamycin.

Authors:  A B Rodriguez; C Barriga; M de la Fuente
Journal:  Agents Actions       Date:  1990-08

9.  Enhanced immune responses in mice treated with penicillin-tetracycline or trimethoprim-sulfamethoxazole when colonized intragastrically with Candida albicans.

Authors:  J E Domer; R F Hector
Journal:  Antimicrob Agents Chemother       Date:  1987-05       Impact factor: 5.191

10.  Stimulation of granulocyte functions in vitro by imipenem and the renal enzyme inhibitor MK 0791.

Authors:  H Gnarpe; J Belsheim; C Blomqvist; A Lundbäck
Journal:  Antimicrob Agents Chemother       Date:  1984-02       Impact factor: 5.191
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.