Literature DB >> 7017932

Nalidixic acid, oxolinic acid, and novobiocin inhibit yeast glycyl- and leucyl-transfer RNA synthetases.

H T Wright, K C Nurse, D J Goldstein.   

Abstract

Nalidixic acid and novobiocin inhibit the aminoacylation and pyrophosphate exchange activities of glycyl- and leucyl-transfer RNA synthetases from bakers' yeast. Similar types of inhibition are observed for both enzymes, suggesting similar mechanisms. The potency of these inhibitors is comparable to that observed for their inhibition of in vivo DNA synthesis in eukaryotic cells.

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Year:  1981        PMID： 7017932     DOI： 10.1126/science.7017932

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  10 in total

1.  Avian myeloblastosis virus reverse transcriptase inhibition by nalidixic acid.

Authors:  H Aoyama
Journal:  Mol Cell Biochem       Date:  1991-12-11       Impact factor: 3.396

Review 2.  Inhibitory effects of quinolone antibacterial agents on eucaryotic topoisomerases and related test systems.

Authors:  T D Gootz; J F Barrett; J A Sutcliffe
Journal:  Antimicrob Agents Chemother       Date:  1990-01       Impact factor: 5.191

3.  The effect of novobiocin on yeast topoisomerase type II.

Authors:  M J Pocklington; J R Jenkins; E Orr
Journal:  Mol Gen Genet       Date:  1990-01

Review 4.  Higher eukaryotic aminoacyl-tRNA synthetases in physiologic and pathologic states.

Authors:  C V Dang; C V Dang
Journal:  Mol Cell Biochem       Date:  1986-08       Impact factor: 3.396

5.  Rapid reversible changes in the rate of histone gene transcription and histone mRNA levels in mouse myeloma cells.

Authors:  R A Graves; W F Marzluff
Journal:  Mol Cell Biol       Date:  1984-02       Impact factor: 4.272

6.  Novobiocin inhibits RNA polymerase III transcription in vitro by a mechanism distinct from DNA topoisomerase II.

Authors:  J M Gottesfeld
Journal:  Nucleic Acids Res       Date:  1986-03-11       Impact factor: 16.971

7.  Effect of 4-quinolones and novobiocin on calf thymus DNA polymerase alpha primase complex, topoisomerases I and II, and growth of mammalian lymphoblasts.

Authors:  P Hussy; G Maass; B Tümmler; F Grosse; U Schomburg
Journal:  Antimicrob Agents Chemother       Date:  1986-06       Impact factor: 5.191

8.  Novobiocin antagonism of amastigotes of Trypanosoma cruzi growing in cell-free medium.

Authors:  P G Pate; J S Wolfson; G L McHugh; S C Pan; M N Swartz
Journal:  Antimicrob Agents Chemother       Date:  1986-03       Impact factor: 5.191

Review 9.  Cinoxacin. A review of its pharmacological properties and therapeutic efficacy in the treatment of urinary tract infections.

Authors:  T S Sisca; R C Heel; J A Romankiewicz
Journal:  Drugs       Date:  1983-06       Impact factor: 9.546

10.  Adenovirus cores can function as templates in in vitro DNA replication.

Authors:  C R Goding; W C Russell
Journal:  EMBO J       Date:  1983       Impact factor: 11.598
  10 in total

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