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Literature DB >> 11894947

Adenovirus cores can function as templates in in vitro DNA replication.

Abstract

Adenovirus cores prepared by gentle disruption of virus by heating at 56 degrees C in the presence of deoxycholate were able to function as templates in an in vitro DNA replication system, allowing both initiation, indicated by the formation of terminal protein-dCMP complex, and elongation of > 300 nucleotides. Using both cores and DNA-protein complexes as templates, it was also demonstrated that novobiocin, an inhibitor of DNA gyrase, inhibited in vitro DNA replication by preventing formation of the initiation complex.

Entities: Chemical

Mesh：

Substances：

Year: 1983 PMID： 11894947 PMCID： PMC555138 DOI： 10.1002/j.1460-2075.1983.tb01428.x

Source DB: PubMed Journal: EMBO J ISSN： 0261-4189 Impact factor: 11.598

35 in total

1. Characterization of the effect of aphidicolin on adenovirus DNA replication: evidence in support of a protein primer model of initiation.

Authors: S Pincus; W Robertson; D Rekosh
Journal: Nucleic Acids Res Date: 1981-10-10 Impact factor: 16.971

2. Adenovirus DNA replication in vitro: purification of the terminal protein in a functional form.

Authors: T Enomoto; J H Lichy; J E Ikeda; J Hurwitz
Journal: Proc Natl Acad Sci U S A Date: 1981-11 Impact factor: 11.205

3. Adenovirus DNA replication in vitro: characterization of a protein covalently linked to nascent DNA strands.

Authors: M D Challberg; S V Desiderio; T J Kelly
Journal: Proc Natl Acad Sci U S A Date: 1980-09 Impact factor: 11.205

4. The 2.2 kb E1b mRNA of human Ad12 and Ad5 codes for two tumor antigens starting at different AUG triplets.

Authors: J L Bos; L J Polder; R Bernards; P I Schrier; P J van den Elsen; A J van der Eb; H van Ormondt
Journal: Cell Date: 1981-11 Impact factor: 41.582

5. Identification of the gene and mRNA for the adenovirus terminal protein precursor.

Authors: B W Stillman; J B Lewis; L T Chow; M B Mathews; J E Smart
Journal: Cell Date: 1981-02 Impact factor: 41.582

6. Monoclonal antibodies against adenovirus type 5: preparation and preliminary characterization.

Authors: W C Russell; G Patel; B Precious; I Sharp; P S Gardner
Journal: J Gen Virol Date: 1981-10 Impact factor: 3.891

7. Effects of novobiocin on adenovirus DNA synthesis and encapsidation.

Authors: J C D'Halluin; M Milleville; P Boulanger
Journal: Nucleic Acids Res Date: 1980-04-11 Impact factor: 16.971

8. Nalidixic acid, oxolinic acid, and novobiocin inhibit yeast glycyl- and leucyl-transfer RNA synthetases.

Authors: H T Wright; K C Nurse; D J Goldstein
Journal: Science Date: 1981-07-24 Impact factor: 47.728

9. Formation of a covalent complex between the 80,000-dalton adenovirus terminal protein and 5'-dCMP in vitro.

Authors: J H Lichy; M S Horwitz; J Hurwitz
Journal: Proc Natl Acad Sci U S A Date: 1981-05 Impact factor: 11.205

10. Initiation of adenovirus DNA replication: detection of covalent complexes between nucleotide and the 80-kilodalton terminal protein.

Authors: M D Challberg; J M Ostrove; T J Kelly
Journal: J Virol Date: 1982-01 Impact factor: 5.103

7 in total

Adenovirus cores can function as templates in in vitro DNA replication.

1. Characterization of the effect of aphidicolin on adenovirus DNA replication: evidence in support of a protein primer model of initiation.

2. Adenovirus DNA replication in vitro: purification of the terminal protein in a functional form.

3. Adenovirus DNA replication in vitro: characterization of a protein covalently linked to nascent DNA strands.

4. The 2.2 kb E1b mRNA of human Ad12 and Ad5 codes for two tumor antigens starting at different AUG triplets.

5. Identification of the gene and mRNA for the adenovirus terminal protein precursor.

6. Monoclonal antibodies against adenovirus type 5: preparation and preliminary characterization.

7. Effects of novobiocin on adenovirus DNA synthesis and encapsidation.

8. Nalidixic acid, oxolinic acid, and novobiocin inhibit yeast glycyl- and leucyl-transfer RNA synthetases.

9. Formation of a covalent complex between the 80,000-dalton adenovirus terminal protein and 5'-dCMP in vitro.

10. Initiation of adenovirus DNA replication: detection of covalent complexes between nucleotide and the 80-kilodalton terminal protein.

Review 1. Recognition mechanisms in the synthesis of animal virus DNA.

2. Role of preterminal protein processing in adenovirus replication.

Review 3. Assembly and remodeling of viral DNA and RNA replicons regulated by cellular molecular chaperones.

4. Requirement of the adenovirus IVa2 protein for virus assembly.

5. Identification and characterization of a DNA binding domain on the adenovirus IVa2 protein.

6. Binding of pRNA to the N-terminal 14 amino acids of connector protein of bacteriophage phi29.

7. Co-operative interactions between NFI and the adenovirus DNA binding protein at the adenovirus origin of replication.