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Literature DB >> 7011285

Cytoskeletal and muscle-like elements in cochlear hair cells.

Abstract

Monospecific antibodies to actin and to tubulin were used as immunofluorescent probes to evaluate the distribution of microtubules and actin filaments in the organ of Corti in mouse and guinea pig. The results indicate that in cochlear receptor cells actin and actin filaments as well as tubulin and microtubules are integral cytoskeletal elements. The presence of actin suggests a possible contractile mechanism within the sensory cilia whereas tubulin is thought to play an important role in the stability of sensory cells. Both proteins are discussed to form structural elements required for the mechano-chemical coupling in hearing.

Entities: Species

Mesh：

Substances：
Actins
Tubulin

Year: 1981 PMID： 7011285 DOI： 10.1007/bf00665383

Source DB: PubMed Journal: Arch Otorhinolaryngol ISSN： 0302-9530

22 in total

10. Organization of an actin filament-membrane complex. Filament polarity and membrane attachment in the microvilli of intestinal epithelial cells.

Authors: M S Mooseker; L G Tilney
Journal: J Cell Biol Date: 1975-12 Impact factor: 10.539

7 in total

4. Correlative immuno-electron-microscopic and immunofluorescent localization of actin in sensory and supporting cells of the inner ear by use of a low-temperature embedding resin.

Authors: N Slepecky; S C Chamberlain
Journal: Cell Tissue Res Date: 1986 Impact factor: 5.249

5. Tropomyosin co-localizes with actin microfilaments and microtubules within supporting cells of the inner ear.

Authors: N Slepecky; S C Chamberlain
Journal: Cell Tissue Res Date: 1987-04 Impact factor: 5.249

6. Immunofluorescence localizations of proteins in semithin 0.2--1 micron frozen sections of the ear. A report of improved techniques including gelatin encapsulation and cryoultramicrotomy.

Authors: A Flock; Y Hoppe; X Wei
Journal: Arch Otorhinolaryngol Date: 1981

7. Inhibition of myosin light-chain kinase activity in the organ of Corti by 0.3-5 kilodalton substances of the otosclerotic perilymph.

Authors: I Sziklai; J G Kiss; O Ribári
Journal: Arch Otorhinolaryngol Date: 1986

7 in total

Cytoskeletal and muscle-like elements in cochlear hair cells.

1. Immunofluorescence of mitotic spindles by using monospecific antibody against bovine brain tubulin.

2. Fluorescence techniques for following interactions of microtubule subunits and membranes.

3. Restriction of the mobility of lymphocyte immunoglobulin receptors by concanavalin A.

4. Muscle-like contractile proteins and tubulin in synaptosomes.

5. Microtubule assembly in the absence of added nucleotides.

6. Tension generation by actomyosin thread from a non-muscle system.

7. Phalloidin-induced cholestasis: a microfilament-mediated change in junctional complex permeability.

8. Pressure-induced depolymerization of spindle microtubules. III. Differential stability in HeLa cells.

9. The organization of actin filaments in the stereocilia of cochlear hair cells.

10. Organization of an actin filament-membrane complex. Filament polarity and membrane attachment in the microvilli of intestinal epithelial cells.

Review 1. Outer hair cell electromotility and otoacoustic emissions.

2. Hearing loss in facioscapulohumeral dystrophy.

3. Osmotically induced motility of outer hair cells: implications for Menière's disease.

4. Correlative immuno-electron-microscopic and immunofluorescent localization of actin in sensory and supporting cells of the inner ear by use of a low-temperature embedding resin.

5. Tropomyosin co-localizes with actin microfilaments and microtubules within supporting cells of the inner ear.

6. Immunofluorescence localizations of proteins in semithin 0.2--1 micron frozen sections of the ear. A report of improved techniques including gelatin encapsulation and cryoultramicrotomy.

7. Inhibition of myosin light-chain kinase activity in the organ of Corti by 0.3-5 kilodalton substances of the otosclerotic perilymph.