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Literature DB >> 7007870

Stimulation of insulin release by L-glutamine.

Abstract

Under normal environmental conditions, L-glutamine is well oxidized but fails to stimulate insulin release in rat pancreatic islets. However, a marked stimulation of insulin release by L-glutamine, without alteration in its oxidation rate occurs when the intracellular pH of the islet cells is decreased and/or when theophylline is added to the incubation medium.

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Year: 1980 PMID： 7007870 DOI： 10.1007/bf00225288

Source DB: PubMed Journal: Mol Cell Biochem ISSN： 0300-8177 Impact factor: 3.396

14 in total

1. The stimulus secretion coupling of glucose-induced insulin release.

Authors: W J Malaisse; S Kawazu; A Herchuelz; J C Hutton; G Somers; G Devis; A Sener
Journal: Arch Biochem Biophys Date: 1979-04-15 Impact factor: 4.013

2. The stimulus-secretion coupling of glucose-induced insulin release. XI. Effects of theophylline and epinephrine on Ca efflux from perifused islets.

Authors: G R Brisson; W J Malaisse
Journal: Metabolism Date: 1973-03 Impact factor: 8.694

3. The stimulus-secretion coupling of glucose-induced insulin release. I. Interaction of epinephrine and alkaline earth cations.

Authors: W J Malaisse; G Brisson; F Malaisse-Lagae
Journal: J Lab Clin Med Date: 1970-12

Review 4. The possible significance of intracellular pH in insulin release.

Authors: W J Malaisse; A Herchuelz; A Sener
Journal: Life Sci Date: 1980-04-28 Impact factor: 5.037

Review 5. Insulin release: the fuel hypothesis.

Authors: W J Malaisse; A Sener; A Herchuelz; J C Hutton
Journal: Metabolism Date: 1979-04 Impact factor: 8.694

6. Similarities in the stimulus-secretion coupling mechanisms of glucose- and 2-keto acid-induced insulin release.

Authors: J C Hutton; A Sener; A Herchuelz; I Atwater; S Kawazu; A C Boschero; G Somers; G Devis; W J Malaisse
Journal: Endocrinology Date: 1980-01 Impact factor: 4.736

7. The stimulus-secretion coupling of glucose-induced insulin release. Does glycolysis control calcium transport in the B-cell?

Authors: A Sener; J Levy; W J Malaisse
Journal: Biochem J Date: 1976-06-15 Impact factor: 3.857

8. The stimulus-secretion coupling of glucose-induced insulin release. VII. A proposed site of action for adenosine-3',5'-cyclic monophosphate.

Authors: G R Brisson; F Malaisse-Lagae; W J Malaisse
Journal: J Clin Invest Date: 1972-02 Impact factor: 14.808

9. The stimulus-secretion coupling of amino acid-induced insulin release. II. Sensitivity to K+, NH4+ and H+ of leucine-stimulated islets.

Authors: A Sener; W J Malaisse
Journal: Diabete Metab Date: 1980-06

10. Stimulus-secretion coupling of glucose-induced insulin release. Effect of intracellular acidification upon calcium efflux from islet cells.

Authors: A R Carpinelli; A Sener; A Herchuelz; W J Malaisse
Journal: Metabolism Date: 1980-06 Impact factor: 8.694

7 in total

Stimulation of insulin release by L-glutamine.

1. The stimulus secretion coupling of glucose-induced insulin release.

2. The stimulus-secretion coupling of glucose-induced insulin release. XI. Effects of theophylline and epinephrine on Ca efflux from perifused islets.

3. The stimulus-secretion coupling of glucose-induced insulin release. I. Interaction of epinephrine and alkaline earth cations.

Review 4. The possible significance of intracellular pH in insulin release.

Review 5. Insulin release: the fuel hypothesis.

6. Similarities in the stimulus-secretion coupling mechanisms of glucose- and 2-keto acid-induced insulin release.

7. The stimulus-secretion coupling of glucose-induced insulin release. Does glycolysis control calcium transport in the B-cell?

8. The stimulus-secretion coupling of glucose-induced insulin release. VII. A proposed site of action for adenosine-3',5'-cyclic monophosphate.

9. The stimulus-secretion coupling of amino acid-induced insulin release. II. Sensitivity to K+, NH4+ and H+ of leucine-stimulated islets.

10. Stimulus-secretion coupling of glucose-induced insulin release. Effect of intracellular acidification upon calcium efflux from islet cells.

1. ATP-independent glucose stimulation of sphingosine kinase in rat pancreatic islets.

2. Adenine nucleotide pattern in rat pancreatic islets exposed to nutrient secretagogues.

3. Conversion into GABA (gamma-aminobutyric acid) may reduce the capacity of L-glutamine as an insulin secretagogue.

4. Mechanism of 3-phenylpyruvate-induced insulin release. Secretory, ionic and oxidative aspects.

5. Insulin release: reconciliation of the receptor and metabolic hypotheses. Nutrient receptors in islet cells.

6. Pancreatic beta-cell purification by altering FAD and NAD(P)H metabolism.

Review 7. Multiple Forms of Glutamate Dehydrogenase in Animals: Structural Determinants and Physiological Implications.