Literature DB >> 7007444

Activation of complement by renal tissues from patients with IgA nephropathy.

Y Tomino, M Endoh, Y Nomoto, H Sakai.   

Abstract

In a study of complement activation by renal tissues, renal biopsy specimens were obtained from patients with IgA nephropathy and other glomerular diseases. These specimens were incubated with freshly frozen guinea-pig serum, and the activation of guinea-pig complement systems was evaluated by immunofluorescent staining with FITC-conjugated anti-guinea-pig complement antisera. It was shown that the alternative pathway of the complement was activated in situ in renal tissues from patients with IgA nephropathy. it is suggested that analysis of in situ activation of complement in such patients is useful for elucidating the mechanism of complement activation in various glomerular diseases.

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Year:  1981        PMID： 7007444      PMCID： PMC1146405          DOI： 10.1136/jcp.34.1.35

Source DB:  PubMed          Journal:  J Clin Pathol        ISSN： 0021-9746            Impact factor:   3.411


  6 in total

1.  Immunoglobulin A nephropathy.

Authors:  S W Zimmerman; P M Burkholder
Journal:  Arch Intern Med       Date:  1975-09

2.  IgA nephropathy.

Authors:  R C McCoy; C R Abramowsky; C C Tisher
Journal:  Am J Pathol       Date:  1974-07       Impact factor: 4.307

3.  Glomerular deposition of properdin in Henoch-Schönlein syndrome and idiopathic focal nephritis.

Authors:  D J Evans; D G Williams; D K Peters; J G Sissons; J M Boulton-Jones; C S Ogg; J S Cameron; B I Hoffbrand
Journal:  Br Med J       Date:  1973-08-11

4.  The C3-activator system: an alternate pathway of complement activation.

Authors:  O Götze; H J Müller-Eberhard
Journal:  J Exp Med       Date:  1971-09-01       Impact factor: 14.307

5.  IgA glomerular deposits in renal disease.

Authors:  J Berger
Journal:  Transplant Proc       Date:  1969-12       Impact factor: 1.066

6.  B.T.PABA test: a new absorption test.

Authors:  M Miwa; I Senoue; H Watanabe; T Nomiyama; R Sakita; S Suzuki; S Harasawa; N Tani; T Miwa
Journal:  Tokai J Exp Clin Med       Date:  1980-01
  6 in total
  4 in total

Review 1.  Pathogenesis of immunoglobulin A nephropathy: recent insight from genetic studies.

Authors:  Krzysztof Kiryluk; Jan Novak; Ali G Gharavi
Journal:  Annu Rev Med       Date:  2012-10-16       Impact factor: 13.739

Review 2.  Mesangial IgA nephritis.

Authors:  A J Woodroffe; A R Clarkson; A E Seymour; J D Lomax-Smith
Journal:  Springer Semin Immunopathol       Date:  1982

3.  Immunofluorescent studies on S-protein in glomeruli from patients with IgA nephropathy.

Authors:  Y Tomino; M Yagame; K Eguchi; Y Nomoto; H Sakai
Journal:  Am J Pathol       Date:  1987-11       Impact factor: 4.307

4.  Detection of IgA-class circulating immune complexes (CIC) in sera from patients with IgA nephropathy using a solid-phase anti-C3 Facb enzyme immunoassay (EIA).

Authors:  M Yagame; Y Tomino; M Miura; T Tanigaki; T Suga; Y Nomoto; H Sakai
Journal:  Clin Exp Immunol       Date:  1987-02       Impact factor: 4.330
  4 in total

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