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Literature DB >> 4579400

Glomerular deposition of properdin in Henoch-Schönlein syndrome and idiopathic focal nephritis.

D J Evans, D G Williams, D K Peters, J G Sissons, J M Boulton-Jones, C S Ogg, J S Cameron, B I Hoffbrand.

Abstract

Biopsy of renal tissue from four patients with idiopathic focal nephritis and three patients with Henoch-Schönlein syndrome showed that C3 and properdin were deposited with IgA in the glomerular mesangium, C1q could not be detected. These observations suggest that glomerular injury in disorders characterized by mesangial deposits of IgA and C3 is mediated via the properdin system.

Entities: Disease Gene Species

Mesh：

Substances：

Year: 1973 PMID： 4579400 PMCID： PMC1586453 DOI： 10.1136/bmj.3.5875.326

Source DB: PubMed Journal: Br Med J ISSN： 0007-1447

12 in total

1. Focal glomerulonephritis. A study based on renal biopsies.

Authors: R H HEPTINSTALL; A M JOEKES
Journal: Q J Med Date: 1959-07

2. Reaction mechanism of the alternative pathway of complement fixation.

Authors: P J Lachmann; P Nicol
Journal: Lancet Date: 1973-03-03 Impact factor: 79.321

3. Role of C3b in the breakdown of C3 in hypocomplementaemic mesangiocapillary glomerulonephritis.

Authors: D G Williams; P J Lachmann; J A Charlesworth; D K Peters
Journal: Lancet Date: 1973-03-03 Impact factor: 79.321

4. Glomerular and dermal depostion of properdin in systemic lupus erythematosus.

Authors: N Rothfield; H A Ross; J O Minta; I H Lepow
Journal: N Engl J Med Date: 1972-10-05 Impact factor: 91.245

5. IgA glomerular deposits in renal disease.

Authors: J Berger
Journal: Transplant Proc Date: 1969-12 Impact factor: 1.066

6. Serum C'3 lytic system in patients with glomerulonephritis.

Authors: R E Spitzer; E H Vallota; J Forristal; E Sudora; A Stitzel; N C Davis; C D West
Journal: Science Date: 1969-04-25 Impact factor: 47.728

7. Glomerular deposition of properdin in acute and chronic glomerulonephritis with hypocomplementemia.

Authors: N G Westberg; G B Naff; J T Boyer; A F Michael
Journal: J Clin Invest Date: 1971-03 Impact factor: 14.808

8. C3 inactivating factor in the serum of a patient with chronic hypocomplementaemic proliferative glomerulo-nephritis.

Authors: R A Thompson
Journal: Immunology Date: 1972-01 Impact factor: 7.397

9. Complement studies in membrano-proliferative glomerulonephritis.

Authors: D K Peters; A Martin; A Weinstein; J S Cameron; T M Barratt; C S Ogg; P J Lachmann
Journal: Clin Exp Immunol Date: 1972-07 Impact factor: 4.330

10. The glomerular mesangium. 3. Acute immune mesangial injury: a new model of glomerulonephritis.

Authors: S M Mauer; D E Sutherland; R J Howard; A J Fish; J S Najarian; A F Michael
Journal: J Exp Med Date: 1973-03-01 Impact factor: 14.307

39 in total

1. Segmental glomerulonephritis.

Authors: M S Dunnill; P R Millard
Journal: J Clin Pathol Date: 1975-03 Impact factor: 3.411

2. Recovery from Goodpasture's syndrome after immunosuppressive treatment and plasmapheresis.

Authors: C M Lockwood; J M Boulton-Jones; R M Lowenthal; I J Simpson; D K Peters
Journal: Br Med J Date: 1975-05-03

Review 3. The rheumatic poison: a survey of some published investigations of the immunopathogenesis of Henoch-Schönlein purpura.

Authors: J F Knight
Journal: Pediatr Nephrol Date: 1990-09 Impact factor: 3.714

Glomerular deposition of properdin in Henoch-Schönlein syndrome and idiopathic focal nephritis.

1. Focal glomerulonephritis. A study based on renal biopsies.

2. Reaction mechanism of the alternative pathway of complement fixation.

3. Role of C3b in the breakdown of C3 in hypocomplementaemic mesangiocapillary glomerulonephritis.

4. Glomerular and dermal depostion of properdin in systemic lupus erythematosus.

5. IgA glomerular deposits in renal disease.

6. Serum C'3 lytic system in patients with glomerulonephritis.

7. Glomerular deposition of properdin in acute and chronic glomerulonephritis with hypocomplementemia.

8. C3 inactivating factor in the serum of a patient with chronic hypocomplementaemic proliferative glomerulo-nephritis.

9. Complement studies in membrano-proliferative glomerulonephritis.

10. The glomerular mesangium. 3. Acute immune mesangial injury: a new model of glomerulonephritis.

1. Segmental glomerulonephritis.

2. Recovery from Goodpasture's syndrome after immunosuppressive treatment and plasmapheresis.

Review 3. The rheumatic poison: a survey of some published investigations of the immunopathogenesis of Henoch-Schönlein purpura.

4. IgA-nephropathy (IgA-IgG-nephropathy/IgA-nephritis)--a disease entity?

5. Symptoms and immunology of the Henoch-Schönlein-syndrome.

6. IgA nephropathy-An immunopathological study.

7. Quantitative elution studies in experimental immune complex and nephrotoxic nephritis.

8. Delayed removal of renal-bound antigen in decomplemented rabbits with acute serum sickness.

9. IgA glomerulonephritis. Mesangial IgA deposition without systemic signs (Berger's disease).

Review 10. Pathogenesis of Henoch-Schönlein purpura nephritis.