Literature DB >> 7007061

The influence of folic acid on the frequency of epileptic attacks.

F B Gibberd, A Nicholls, M G Wright.   

Abstract

A double blind trial of folic acid against placebo was carried out on out-patients with epilepsy treated with Phenytoin. There was a minimum period on treatment of one year. While the group receiving folic acid in the treatment period showed a significant improvement in seizure frequency, the placebo group also showed some improvement. It is concluded that the improvement while on folic acid was not due to the folic acid treatment alone. The subjective well-being of patients was not influenced by folic acid therapy.

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Year:  1981        PMID： 7007061     DOI： 10.1007/bf00558385

Source DB:  PubMed          Journal:  Eur J Clin Pharmacol        ISSN： 0031-6970            Impact factor:   2.953


  14 in total

1.  Studies in man of phenytoin absorption and its implications.

Authors:  F B Gibberd; M Webley
Journal:  J Neurol Neurosurg Psychiatry       Date:  1975-03       Impact factor: 10.154

2.  The epileptogenic action of Na-folate in the rat.

Authors:  O R Hommes; E A Obbens
Journal:  J Neurol Sci       Date:  1972-07       Impact factor: 3.181

Review 3.  Anticonvulsants, folic acid, and epilepsy.

Authors:  E H Reynolds
Journal:  Lancet       Date:  1973-06-16       Impact factor: 79.321

4.  Effects of folic acid on fit-frequency and behaviour in epileptics on anticonvulsants.

Authors:  A J Ralston; R P Snaith; J B Hinley
Journal:  Lancet       Date:  1970-04-25       Impact factor: 79.321

5.  The effect of anticonvulsant therapy upon the absorption of folates.

Authors:  C Fehling; M Jägerstad; K Lindstrand; A K Westesson
Journal:  Clin Sci       Date:  1973-06       Impact factor: 6.124

6.  Mechanism of folate deficiency in patients receiving phenytoin.

Authors:  A V Hoffbrand; T F Necheles
Journal:  Lancet       Date:  1968-09-07       Impact factor: 79.321

7.  Impairment of intestinal deconjugation of dietary folate. A possible explanation of megaloblastic anaemia associated with phenytoin therapy.

Authors:  I H Rosenberg; H A Godwin; R R Streiff; W B Castle
Journal:  Lancet       Date:  1968-09-07       Impact factor: 79.321

8.  Folic acid deficiency in patients receiving anticonvulsant drugs.

Authors:  R E Davis; H J Woodliff
Journal:  Med J Aust       Date:  1971-11-20       Impact factor: 7.738

9.  Macrocytosis in patients on anticonvulsant drugs.

Authors:  J A Child; B Z Khattak; J P Knowles
Journal:  Br J Haematol       Date:  1969-05       Impact factor: 6.998

10.  Folic acid in folate-deficient patients with epilepsy.

Authors:  R H Grant; O P Stores
Journal:  Br Med J       Date:  1970-12-12
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  6 in total

1.  Effect of Folic Acid Supplementation on Seizure Control in Epileptic Children Receiving Long Term Antiepileptic Therapy.

Authors:  Bindu Deopa; Manish Parakh; Pawan Dara; Vikas Payal; Kapil Chordiya; Ankit Panday; Sumeet Singh; Devesh Parashar
Journal:  Indian J Pediatr       Date:  2018-01-25       Impact factor: 1.967

2.  Anticonvulsive effect of folic acid in homocysteine thiolactone-induced seizures.

Authors:  Aleksandra Rašić Marković; Dragan Hrnčić; Djuro Macut; Olivera Stanojlović; Dragan Djuric
Journal:  Cell Mol Neurobiol       Date:  2011-06-22       Impact factor: 5.046

Review 3.  Drugs and folate metabolism.

Authors:  D G Lambie; R H Johnson
Journal:  Drugs       Date:  1985-08       Impact factor: 9.546

Review 4.  Vitamin neurotoxicity.

Authors:  S R Snodgrass
Journal:  Mol Neurobiol       Date:  1992       Impact factor: 5.590

5.  Folic acid fortification of grain: an economic analysis.

Authors:  P S Romano; N J Waitzman; R M Scheffler; R D Pi
Journal:  Am J Public Health       Date:  1995-05       Impact factor: 9.308

Review 6.  Issues in the prevention of spina bifida.

Authors:  C Bower; F J Stanley
Journal:  J R Soc Med       Date:  1996-08       Impact factor: 18.000
  6 in total

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