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Literature DB >> 1151402

Studies in man of phenytoin absorption and its implications.

Abstract

The absorption of phenytoin was studied in man. It is concluded that phenytoin absorbed from the intestine is recirculated via the bile, so that blood levels do not accurately reflect absorption. Phenytoin is loosely bound to serum proteins and is found in red cells in concentrations similar to those in plasma. It is rapidly lost from the blood stream after intravenous administration, which is an important factor to be considered in the treatment of status epilepticus.

Entities: Chemical Disease Species

Mesh：

Substances：
Blood Proteins
Phenytoin

Year: 1975 PMID： 1151402 PMCID： PMC491899 DOI： 10.1136/jnnp.38.3.219

Source DB: PubMed Journal: J Neurol Neurosurg Psychiatry ISSN： 0022-3050 Impact factor: 10.154

13 in total

1. Determination of diphenylhydantoin and phenobarbital in small amounts of serum.

Authors: O SVENSMARK; P KRISTENSEN
Journal: J Lab Clin Med Date: 1963-03

2. Studies on 5, 5'-diphenylhydantoin (dilantin) in animals and man.

Authors: W A DILL; A J GLAZKO; A KAZENKO; L M WOLF
Journal: J Pharmacol Exp Ther Date: 1956-11 Impact factor: 4.030

3. Plasma protein binding of diphenylhydantoin in man. Interaction with other drugs and the effect of temperature and plasma dilution.

Authors: P K Lunde; A Rane; S J Yaffe; L Lund; F Sjöqvist
Journal: Clin Pharmacol Ther Date: 1970 Nov-Dec Impact factor: 6.875

Studies in man of phenytoin absorption and its implications.

1. Determination of diphenylhydantoin and phenobarbital in small amounts of serum.

2. Studies on 5, 5'-diphenylhydantoin (dilantin) in animals and man.

3. Plasma protein binding of diphenylhydantoin in man. Interaction with other drugs and the effect of temperature and plasma dilution.

4. Plasma protein binding of tricyclic anti-depressants in man.

5. Rapid determination of diphenylhydantoin in blood plasma by gas-liquid chromatography.

6. Metabolic disposition of diphenylhydantoin in normal human subjects following intravenous administration.

7. Serum protein binding of thyroxine and diphenylhydantoin.

8. Plasma protein binding, plasma concentrations, and effects of diphenylhydantoin in man.

9. Studies on the metabolism of diphenylhydantoin (Dilantin).

10. Phenytoin tolerance tests.

1. The influence of folic acid on the frequency of epileptic attacks.

Review 2. The treatment of autism with low-dose phenytoin: a case report.