Literature DB >> 7000593

Increased prostacyclin release from perfused hearts of acutely diabetic rats.

P Rösen, K Schrör.   

Abstract

The release of prostacyclin and PGE2 from the isolated perfused hearts of acutely diabetic (streptozotocin 100 mg/kg) rats was studied and compared with hearts from control animals. Prostacyclin and PGE2 were measured by a differential bioassay technique. No basal release of either prostaglandin ws detected. However, after addition of arachidonic acid, a dose dependent release of prostacyclin and PGE2 was noted. Prostacyclin was identified as the major prostaglandin. Release of prostacyclin and PGE2 from acutely diabetic rat hearts was increased 2-3 times compared to control hearts. No release of prostaglandin endoperoxides was observed in either group of hearts.

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Year:  1980        PMID： 7000593     DOI： 10.1007/bf00276820

Source DB:  PubMed          Journal:  Diabetologia        ISSN： 0012-186X            Impact factor:   10.122


  15 in total

1.  Arachidonic acid metabolites and the interactions between platelets and blood-vessel walls.

Authors:  S Moncada; J R Vane
Journal:  N Engl J Med       Date:  1979-05-17       Impact factor: 91.245

2.  Decreased vascular prostacyclin in juvenile-onset diabetes.

Authors:  K Silberbauer; G Schernthaner; H Sinzinger; H Piza-Katzer; M Winter
Journal:  N Engl J Med       Date:  1979-02-15       Impact factor: 91.245

3.  Prostacyclin and thromboxane A2 biosynthesis capacities of heart, arteries and platelets at various stages of experimental atherosclerosis in rabbits.

Authors:  R J Gryglewski; A Dembińska-Kièć; A Zmuda; T Gryglewska
Journal:  Atherosclerosis       Date:  1978-12       Impact factor: 5.162

4.  Prostacyclin is the major prostaglandin released from the isolated perfused rabbit and rat heart.

Authors:  E A de Deckere; D H Nugteren; F Ten Hoor
Journal:  Nature       Date:  1977-07-14       Impact factor: 49.962

5.  Coronary arterial smooth muscle contraction by a substance released from platelets: evidence that it is thromboxane A2.

Authors:  E F Ellis; O Oelz; L J Roberts; N A Payne; B J Sweetman; A S Nies; J A Oates
Journal:  Science       Date:  1976-09-17       Impact factor: 47.728

6.  Anoxia-induced release of prostaglandins in rabbit isolated hearts.

Authors:  A J Block; H Feinberg; K Herbaczynska-Cedro; J R Vane
Journal:  Circ Res       Date:  1975-01       Impact factor: 17.367

7.  Transformation of arachidonic acid and prostaglandin endoperoxides by the guinea pig heart. Formation of RCS and prostacyclin.

Authors:  K Schrör; S Moncada; F B Ubatuba; J R Vane
Journal:  Eur J Pharmacol       Date:  1978-01-01       Impact factor: 4.432

8.  Effect of fasting and streptozotocin-diabetes on the coronary flow in isolated rat hearts: A possible role of endogenous catecholamines and prostaglandins.

Authors:  H Stam; W C Hülsmann
Journal:  Basic Res Cardiol       Date:  1977 Jul-Aug       Impact factor: 17.165

9.  Prostacyclin (PGX) is the endogenous metabolite responsible for relaxation of coronary arteries induced by arachindonic acid.

Authors:  G J Dusting; S Moncada; J R Vane
Journal:  Prostaglandins       Date:  1977-01

10.  Human arterial and venous tissues generate prostacyclin (prostaglandin x), a potent inhibitor of platelet aggregation.

Authors:  S Moncada; E A Higgs; J R Vane
Journal:  Lancet       Date:  1977-01-01       Impact factor: 79.321
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  9 in total

1.  Effects on prostaglandins F2 alpha, I2, and indomethacin on isolated coronary arteries from healthy and alloxan-diabetic dogs.

Authors:  I Palik; P Hadházy; K Magyar; B Malomvölgyi; M Wagner; G Pogátsa
Journal:  Experientia       Date:  1981

2.  Involvement of thromboxane and leukotriene in arachidonate induced coronary constriction in diabetic rats.

Authors:  Y Takiguchi; K Umemura; H Hashimoto; M Nakashima
Journal:  Diabetologia       Date:  1989-06       Impact factor: 10.122

3.  Vasoreactivity and prostacyclin release in streptozotocin-diabetic rats: effects of insulin or aldose reductase inhibition.

Authors:  E J Stevens; G B Willars; P Lidbury; F House; D R Tomlinson
Journal:  Br J Pharmacol       Date:  1993-08       Impact factor: 8.739

4.  Glucose-induced protein kinase C activity regulates arachidonic acid release and eicosanoid production by cultured glomerular mesangial cells.

Authors:  B Williams; R W Schrier
Journal:  J Clin Invest       Date:  1993-12       Impact factor: 14.808

5.  Increased prostaglandin production by glomeruli isolated from rats with streptozotocin-induced diabetes mellitus.

Authors:  M Schambelan; S Blake; J Sraer; M Bens; M P Nivez; F Wahbe
Journal:  J Clin Invest       Date:  1985-02       Impact factor: 14.808

6.  Relationship between vascular adrenergic receptors and prostaglandin biosyntheses in canine diabetic coronary arteries.

Authors:  M Z Koltai; P Rösen; P Hadházy; G Ballagi-Pordány; A Köszeghy; G Pogátsa
Journal:  Diabetologia       Date:  1988-09       Impact factor: 10.122

7.  In-vitro venous prostacyclin production, plasma 6-keto-prostaglandin F1 alpha concentrations, and diabetic retinopathy.

Authors:  T M Davis; E Bown; D R Finch; M D Mitchell; R C Turner
Journal:  Br Med J (Clin Res Ed)       Date:  1981-04-18

8.  Vascular responsiveness and eicosanoid production in diabetic rats.

Authors:  D M Roth; D K Reibel; A M Lefer
Journal:  Diabetologia       Date:  1983-05       Impact factor: 10.122

9.  Contractile activity and prostacyclin generation in isolated coronary arteries from diabetic dogs.

Authors:  L Sterin-Borda; E S Borda; M F Gimeno; M A Lazzari; E del Castillo; A L Gimeno
Journal:  Diabetologia       Date:  1982-01       Impact factor: 10.122
  9 in total

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