Literature DB >> 6995326

Immunotherapy of experimental cancer by intralesional injection of emulsified nonliving mycobacteria: comparison of Mycobacterium bovis (BCG), Mycobacterium phlei, and Mycobacterium smegmatis.

E Yarkoni, H J Rapp.   

Abstract

Mycobacterium bovis (BCG), Mycobacterium phlei, and Mycobacterium smegmatis were each tested in emulsified form for their potency to cause regression of transplants of a syngeneic murine fibrosarcoma and of a syngeneic guinea pig hepatoma. On a weight basis, M. phlei and M. smegmatis were as effective as BCG in causing tumor regression. M. phlei and M. smegmatis were comparable to BCG in provoking delayed cutaneous hypersensitivity reactions in guinea pigs sensitized to M. phlei or M. smegmatis. In BCG-sensitized guinea pigs, M. phlei and M. smegmatis provoked weaker delayed cutaneous hypersensitivity reactions than did BCG. Purified protein derivative of M. tuberculosis was more active in eliciting delayed cutaneous hypersensitivity in BCG-sensitized guinea pigs than in animals sensitized with M. phlei or M. smegmatis.

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Year:  1980        PMID： 6995326      PMCID： PMC551034          DOI： 10.1128/iai.28.3.887-892.1980

Source DB:  PubMed          Journal:  Infect Immun        ISSN： 0019-9567            Impact factor:   3.441


  9 in total

1.  Immunotherapy of cancer: regression of established intradermal tumors after intralesional injection of mycobacterial cell walls attached to oil droplets.

Authors:  B Zbar; E Ribi; T Meyer; I Azuma; H J Rapp
Journal:  J Natl Cancer Inst       Date:  1974-05       Impact factor: 13.506

Review 2.  A guinea pig model for tumor immunology. A summary.

Authors:  H J Rapp
Journal:  Isr J Med Sci       Date:  1973-03

3.  Immunotherapy of cancer: tumor suppression and regression by cell walls of Mycobacterium phlei attached to oil droplets.

Authors:  G R Gray; E Ribi; D Granger; R Parker; I Azuma; K Yamamoto
Journal:  J Natl Cancer Inst       Date:  1975-09       Impact factor: 13.506

4.  Tumor regression after intralesional injection of emulsified trehalose-6,6'-dimycolate (cord factor): efficacy increases with oil concentration.

Authors:  E Yarkoni; M S Meltzer; H J Rapp
Journal:  Int J Cancer       Date:  1977-06-15       Impact factor: 7.396

5.  Influence of oil concentration on the efficacy of tumor regression by emulsified components of mycobacteria.

Authors:  E Yarkoni; H J Rapp
Journal:  Cancer Res       Date:  1979-02       Impact factor: 12.701

6.  Tumor regression after intralesional injection of mycobacterial components emulsified in 2,6,10,15,19,23-hexamethyl-2,6,10,14,18,22-tetracosahexaene (squalene), 2,6,10,15,19,23-hexamethyltetracosane (squalane), peanut oil, or mineral oil.

Authors:  E Yarkoni; H J Rapp
Journal:  Cancer Res       Date:  1979-05       Impact factor: 12.701

7.  Immunotherapy of guinea pigs with a transplanted hepatoma: comparison of intralesionally administered killed BCG cells and BCG cell walls.

Authors:  E Yarkoni; H J Rapp
Journal:  Infect Immun       Date:  1979-09       Impact factor: 3.441

8.  Intralesional immunotherapy of malignant melanoma with mycobacterium smegmatis cell wall skeleton combined with trehalose dimycolate (P3).

Authors:  G J Vosika; J R Schmidtke; A Goldman; E Ribi; R Parker; G R Gray
Journal:  Cancer       Date:  1979-08       Impact factor: 6.860

9.  Influence of type of oil and surfactant concentration on the efficacy of emulsified Mycobacterium bovis BCG cell walls to induce tumor regression in guinea pigs.

Authors:  E Yarkoni; H J Rapp
Journal:  Infect Immun       Date:  1980-06       Impact factor: 3.441
  9 in total
  2 in total

1.  Closely related mycobacterial strains demonstrate contrasting levels of efficacy as antitumor vaccines and are processed for major histocompatibility complex class I presentation by multiple routes in dendritic cells.

Authors:  Eleanor J Cheadle; Dearbhaile O'Donnell; Peter J Selby; Andrew M Jackson
Journal:  Infect Immun       Date:  2005-02       Impact factor: 3.441

2.  A specific vaccine effective against stage I and stage II malignant disease in guinea pigs. Effect of variations in preparations and storage.

Authors:  E Yarkoni; J T Hunter; S Sukumar
Journal:  Cancer Immunol Immunother       Date:  1982       Impact factor: 6.968
  2 in total

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