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Literature DB >> 6991878

Curing of Escherichia coli K12 plasmids by coumermycin.

Abstract

Low concentrations of the antibiotic coumermycin A1, the inhibitor of bacterial DNA gyrase, effectively eliminate pBR322, pMB9 and other ColE 1 related plasmids from E. coli K12 strains. The curing action of antibiotic seems to result from the plasmid degradation and not just from the inhibition of replication.

Entities: Chemical Species

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Year: 1980 PMID： 6991878 DOI： 10.1007/bf00267235

Source DB: PubMed Journal: Mol Gen Genet ISSN： 0026-8925

15 in total

1. Mechanism of action of nalidixic acid: purification of Escherichia coli nalA gene product and its relationship to DNA gyrase and a novel nicking-closing enzyme.

Authors: A Sugino; C L Peebles; K N Kreuzer; N R Cozzarelli
Journal: Proc Natl Acad Sci U S A Date: 1977-11 Impact factor: 11.205

2. The effect of rifampicin upon the transcription of RNA polymerase beta-gene in Escherichia coli.

Authors: I A Bass; O N Danilevskaya; S L Mekhedov; V B Fedoseeva; Z M Gorlenko
Journal: Mol Gen Genet Date: 1979-05-23

3. Segregation kinetics of colicinogenic factor col E1 from a bacterial population temperature sensitive for DNA polymerase I.

Authors: B W Durkacz; D J Sherratt
Journal: Mol Gen Genet Date: 1973

Curing of Escherichia coli K12 plasmids by coumermycin.

1. Mechanism of action of nalidixic acid: purification of Escherichia coli nalA gene product and its relationship to DNA gyrase and a novel nicking-closing enzyme.

2. The effect of rifampicin upon the transcription of RNA polymerase beta-gene in Escherichia coli.

3. Segregation kinetics of colicinogenic factor col E1 from a bacterial population temperature sensitive for DNA polymerase I.

4. Direct inhibition of Col E 1 plasmid DNA replication in Escherichia coli by rifampicin.

5. Gel electrophoretic separation of the complementary strands of bacteriophage DNA.

6. Recombination between bacterial plasmids leading to the formation of plasmid multimers.

7. Novobiocin and coumermycin inhibit DNA supercoiling catalyzed by DNA gyrase.

8. Construction and characterization of new cloning vehicles. II. A multipurpose cloning system.

9. DNA gyrase: subunit structure and ATPase activity of the purified enzyme.

10. Isolation of supercoiled colicinogenic factor E 1 DNA sensitive to ribonuclease and alkali.

1. Mutations which alter the elbow region of tRNA2Gly reduce T4 gene 60 translational bypassing efficiency.

2. Drug-induced relaxation of supercoiled plasmid DNA in Bacillus subtilis and induction of the SOS response.

3. Preferential inhibition of plasmid replication in vivo by altered DNA gyrase activity in Escherichia coli.

4. Antagonism of the B subunit of DNA gyrase eliminates plasmids pBR322 and pMG110 from Escherichia coli.

5. TonB-dependent transporter FhuA in planar lipid bilayers: partial exit of its plug from the barrel.

6. Elimination of plasmid pMG110 from Escherichia coli by novobiocin and other inhibitors of DNA gyrase.

7. Chromosomal mutation that affects excretion of hemolysin in Escherichia coli.

8. Elimination of plasmid pKM101 from Salmonella typhimurium by monoammonium salts.

9. Curing effect of clorobiocin on Escherichia coli plasmids.

10. Loss of unstably amplified dihydrofolate reductase genes from mouse cells is greatly accelerated by hydroxyurea.