Literature DB >> 6990413

Intracellular distribution of nerve growth factor in rat pheochromocytoma PC12 cells: evidence for a perinuclear and intranuclear location.

P C Marchisio, L Naldini, P Calissano.   

Abstract

The distribution of nerve growth factor (NGF) in rat pheochromocytoma cells (clone PC12) has been studied with two different techniques: immunofluorescence and autoradiography. It was found that NGF is progressively internalized in the cytoplasmic compartment and eventually accumulates in the form of discrete dots around the nucleus. A fraction of the internalized NGF appears within the nucleoplasm, often contiguous with the nucleolus. It is suggested that cytoplasmic and perinuclear NGF may be be in contact with a pool of tubulin or actin-like proteins in their soluble or organized form and play a key role in the process of arrest of division and neurite growth.

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Year:  1980        PMID： 6990413      PMCID： PMC348556          DOI： 10.1073/pnas.77.3.1656

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  18 in total

1.  EARLY EFFECTS OF ANTISERUM AGAINST THE NERVE GROWTH FACTOR ON FINE STRUCTURE OF SYMPATHETIC NEURONS.

Authors:  M T SABATINI; A PELLEGRINODEIRALDI; E DEROBERTIS
Journal:  Exp Neurol       Date:  1965-08       Impact factor: 5.330

2.  EXCESSIVE GROWTH OF THE SYMPATHETIC GANGLIA EVOKED BY A PROTEIN ISOLATED FROM MOUSE SALIVARY GLANDS.

Authors:  R Levi-Montalcini; B Booker
Journal:  Proc Natl Acad Sci U S A       Date:  1960-03       Impact factor: 11.205

3.  Specific visualization of tubulin-containing structures in tissue culture cells by immunofluorescence. Cytoplasmic microtubules, vinblastine-induced paracrystals, and mitotic figures.

Authors:  K Weber; T Bibring; M Osborn
Journal:  Exp Cell Res       Date:  1975-10-01       Impact factor: 3.905

Review 4.  Nerve growth factor-induced increase in electrical excitability and acetylcholine sensitivity of a rat pheochromocytoma cell line.

Authors:  M A Dichter; A S Tischler; L A Greene
Journal:  Nature       Date:  1977-08-11       Impact factor: 49.962

5.  Alterations in the fine structure of nucleoli in sympathetic neurons following NGF-antiserum treatment.

Authors:  R Levi-Montalcini; F Caramia; P U Angeletti
Journal:  Brain Res       Date:  1969-01       Impact factor: 3.252

6.  Distribution of actin and tubulin in cells and in glycerinated cell models after treatment with cytochalasin B (CB).

Authors:  K Weber; P C Rathke; M Osborn; W W Franke
Journal:  Exp Cell Res       Date:  1976-10-15       Impact factor: 3.905

7.  The nerve growth factor: purification as a 30,000-molecular-weight protein.

Authors:  V Bocchini; P U Angeletti
Journal:  Proc Natl Acad Sci U S A       Date:  1969-10       Impact factor: 11.205

8.  Nerve growth factor in the nucleus: interaction with receptors on the nuclear membrane.

Authors:  B A Yankner; E M Shooter
Journal:  Proc Natl Acad Sci U S A       Date:  1979-03       Impact factor: 11.205

9.  Nerve growth factor potentiates actomyosin adenosinetriphosphatase.

Authors:  P Calissano; G Monaco; L Castellani; D Mercanti; A Levi
Journal:  Proc Natl Acad Sci U S A       Date:  1978-05       Impact factor: 11.205

10.  Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor.

Authors:  L A Greene; A S Tischler
Journal:  Proc Natl Acad Sci U S A       Date:  1976-07       Impact factor: 11.205
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  8 in total

Review 1.  Regulation of presynaptic cellular function. Biochemical studies using clonal neuronal cells.

Authors:  R McGee
Journal:  Mol Cell Biochem       Date:  1980-12-16       Impact factor: 3.396

Review 2.  The mode of action of nerve growth factor in PC12 cells.

Authors:  A Levi; S Biocca; A Cattaneo; P Calissano
Journal:  Mol Neurobiol       Date:  1988       Impact factor: 5.590

3.  Nuclear localization of SP, CGRP, and NK1R in a subpopulation of dorsal root ganglia subpopulation cells in rats.

Authors:  Patrícia Aline Boer; José Antonio Rocha Gontijo
Journal:  Cell Mol Neurobiol       Date:  2006-05-06       Impact factor: 5.046

4.  Receptor-mediated internalization of fluorescent gonadotropin-releasing hormone by pituitary gonadotropes.

Authors:  E Hazum; P Cuatrecasas; J Marian; P M Conn
Journal:  Proc Natl Acad Sci U S A       Date:  1980-11       Impact factor: 11.205

5.  Microtubules and microfilaments in fixed and permeabilized cells are selectively decorated by nerve growth factor.

Authors:  S Nasi; D Cirillo; L Naldini; P C Marchisio; P Calissano
Journal:  Proc Natl Acad Sci U S A       Date:  1982-02       Impact factor: 11.205

6.  Modulation of nerve growth factor and choline acetyltransferase expression in rat hippocampus after chronic exposure to haloperidol, risperidone, and olanzapine.

Authors:  Vinay Parikh; Alvin V Terry; Mohammad M Khan; Sahebarao P Mahadik
Journal:  Psychopharmacology (Berl)       Date:  2003-11-28       Impact factor: 4.530

7.  High-affinity receptor-mediated internalization and degradation of interleukin 2 in human T cells.

Authors:  M Fujii; K Sugamura; K Sano; M Nakai; K Sugita; Y Hinuma
Journal:  J Exp Med       Date:  1986-03-01       Impact factor: 14.307

8.  Nuclear transport in 3T3 fibroblasts: effects of growth factors, transformation, and cell shape.

Authors:  L W Jiang; M Schindler
Journal:  J Cell Biol       Date:  1988-01       Impact factor: 10.539
  8 in total

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