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Literature DB >> 6987329

Acquisition of cell surface IgD after in vitro culture of neoplastic B cells from the murine tumor BCL1.

P C Isakson, J W Uhr, K A Krolick, F Finkelman, E S Vitetta.

Abstract

Murine BCL1 tumor cells bear large amounts of surface IgM and trace amounts of surface IgD. In the present studies we have shown that cultivation of these cells, in the absence of lipopolysaccharide, results in the acquisition of IgD by virtually all the cells. These results suggest that BCL1 cells can differentiate in vitro into more mature B cells and offer an attractive model for analyzing the factors controlling appearance of IgD on a monoclonal cell line.

Entities: CellLine Chemical Disease Gene Species

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Year: 1980 PMID： 6987329 PMCID： PMC2185800 DOI： 10.1084/jem.151.3.749

Source DB: PubMed Journal: J Exp Med ISSN： 0022-1007 Impact factor: 14.307

10 in total

Review 1. BCL1, a murine model for chronic lymphocytic leukemia: use of the surface immunoglobulin idiotype for the detection and treatment of tumor.

Authors: K A Krolick; P C Isakson; J W Uhr; E S Vitetta
Journal: Immunol Rev Date: 1979 Impact factor: 12.988

2. Spontaneous murine B-cell leukaemia.

Authors: S Slavin; S Strober
Journal: Nature Date: 1978-04-13 Impact factor: 49.962

3. Surface immunoglobulins of lipopolysaccharide-stimulated spleen cells. The behavior of IgM, IgD and IgG.

Authors: A Bourgois; K Kitajima; I R Hunter; B A Askonas
Journal: Eur J Immunol Date: 1977-03 Impact factor: 5.532

Review 4. IgD and B cell differentiation.

Authors: E S Vitetta; J W Uhr
Journal: Immunol Rev Date: 1977 Impact factor: 12.988

5. Rescue of immunoglobulin secretion from human neoplastic lymphoid cells by somatic cell hybridization.

Authors: R Levy; J Dilley
Journal: Proc Natl Acad Sci U S A Date: 1978-05 Impact factor: 11.205

6. Characterization of the spontaneous murine B cell leukemia (BCL1). III. Evidence for monoclonality by using an anti-idiotype antibody.

Authors: E S Vitetta; D Yuan; K Krolick; P Isakson; M Knapp; S Slavin; S Strober
Journal: J Immunol Date: 1979-05 Impact factor: 5.422

7. Characterization of a spontaneous murine B cell leukemia (BCL1). I. Cell surface expression of IgM, IgD, Ia, and FcR.

Authors: M R Knapp; P P Jones; S J Black; E S Vitetta; S Slavin; S Strober
Journal: J Immunol Date: 1979-09 Impact factor: 5.422

8. Murine B cell leukemia (BCL1): organ distribution and kinetics of growth as determined by fluorescence analysis with an anti-idiotypic antibody.

Authors: K A Krolick; P C Isakson; J W Uhr; E S Vitetta
Journal: J Immunol Date: 1979-11 Impact factor: 5.422

9. Characterization of a spontaneous murine B cell leukemia (BCL1). II. Tumor cell proliferation and IgM secretion after stimulation by LPS.

Authors: M R Knapp; E Severinson-Gronowicz; J Schröder; S Strober
Journal: J Immunol Date: 1979-09 Impact factor: 5.422

10. Induction of in vitro differentiation and immunoglobulin synthesis of human leukemic B lymphocytes.

Authors: S M Fu; N Chiorazzi; H G Kunkel; J P Halper; S R Harris
Journal: J Exp Med Date: 1978-12-01 Impact factor: 14.307

10 in total

7 in total

7. Double isotype production by a neoplastic B cell line. II. Allelically excluded production of mu and gamma 1 heavy chains without CH gene rearrangement.

Authors: Y W Chen; C Word; V Dev; J W Uhr; E S Vitetta; P W Tucker
Journal: J Exp Med Date: 1986-08-01 Impact factor: 14.307

7 in total

Acquisition of cell surface IgD after in vitro culture of neoplastic B cells from the murine tumor BCL1.

Review 1. BCL1, a murine model for chronic lymphocytic leukemia: use of the surface immunoglobulin idiotype for the detection and treatment of tumor.

2. Spontaneous murine B-cell leukaemia.

3. Surface immunoglobulins of lipopolysaccharide-stimulated spleen cells. The behavior of IgM, IgD and IgG.

Review 4. IgD and B cell differentiation.

5. Rescue of immunoglobulin secretion from human neoplastic lymphoid cells by somatic cell hybridization.

6. Characterization of the spontaneous murine B cell leukemia (BCL1). III. Evidence for monoclonality by using an anti-idiotype antibody.

7. Characterization of a spontaneous murine B cell leukemia (BCL1). I. Cell surface expression of IgM, IgD, Ia, and FcR.

8. Murine B cell leukemia (BCL1): organ distribution and kinetics of growth as determined by fluorescence analysis with an anti-idiotypic antibody.

9. Characterization of a spontaneous murine B cell leukemia (BCL1). II. Tumor cell proliferation and IgM secretion after stimulation by LPS.

10. Induction of in vitro differentiation and immunoglobulin synthesis of human leukemic B lymphocytes.

1. Secretion of idiotypic IgM by the mouse B-cell leukaemia (BCL1) occurs spontaneously in vitro and in vivo.

Review 2. Treatment of lymphoid tumors with anti-idiotype antibodies.

3. BCL1, a murine model of prolymphocytic leukemia. II. Morphology and ultrastructure.

4. Induction of proliferation and differentiation of neoplastic B cells by anti-immunoglobulin and T-cell factors.

5. Hydroxyurea increases in vitro, antigen-independent B cell development in bone marrow.

6. BCL1, a murine model of prolymphocytic leukemia. I. Effect of splenectomy on growth kinetics and organ distribution.

7. Double isotype production by a neoplastic B cell line. II. Allelically excluded production of mu and gamma 1 heavy chains without CH gene rearrangement.