Literature DB >> 109513

Characterization of the spontaneous murine B cell leukemia (BCL1). III. Evidence for monoclonality by using an anti-idiotype antibody.

E S Vitetta, D Yuan, K Krolick, P Isakson, M Knapp, S Slavin, S Strober.   

Abstract

We have raised an anti-idiotypic antibody against the cell surface IgM of the murine BCL1 tumor cells. This antiserum reacts exclusively with the IgM expressed on the tumor cells and detects a unique population of cells in the spleen and blood of the tumor-bearing mice. When these cells are stimulated in vitro with LPS, they secrete an IgM bearing the same idiotype as the cell surface Ig. These results are discussed in terms of a model for the immunotherapy of a chronic lymphocytic leukemia-like syndrome in mice.

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Year:  1979        PMID： 109513

Source DB:  PubMed          Journal:  J Immunol        ISSN： 0022-1767            Impact factor:   5.422


  16 in total

1.  Activation-specific interactions among B-lymphocyte plasma membrane proteins.

Authors:  M G Goodman; R L Wolfert
Journal:  Immunol Res       Date:  1986       Impact factor: 2.829

2.  Pregnancy-related steroids are potential negative regulators of B lymphopoiesis.

Authors:  K L Medina; P W Kincade
Journal:  Proc Natl Acad Sci U S A       Date:  1994-06-07       Impact factor: 11.205

3.  Experimental models of lymphoproliferative disease. The mouse as a model for human non-Hodgkin's lymphomas and related leukemias.

Authors:  P K Pattengale; C R Taylor
Journal:  Am J Pathol       Date:  1983-11       Impact factor: 4.307

4.  Selective killing of normal or neoplastic B cells by antibodies coupled to the A chain of ricin.

Authors:  K A Krolick; C Villemez; P Isakson; J W Uhr; E S Vitetta
Journal:  Proc Natl Acad Sci U S A       Date:  1980-09       Impact factor: 11.205

5.  Tumor dormancy and cell signaling: anti-mu-induced apoptosis in human B-lymphoma cells is not caused by an APO-1-APO-1 ligand interaction.

Authors:  E Racila; R Hsueh; R Marches; T F Tucker; P H Krammer; R H Scheuermann; J W Uhr
Journal:  Proc Natl Acad Sci U S A       Date:  1996-03-05       Impact factor: 11.205

6.  Immunotherapy of B lymphoma by anti-idiotype antibodies: characterization of variant tumour cells appearing a long time after the initial tumour inoculation.

Authors:  M Taya; J Haimovich
Journal:  Cancer Immunol Immunother       Date:  1991       Impact factor: 6.968

7.  Lyn tyrosine kinase signals cell cycle arrest but not apoptosis in B-lineage lymphoma cells.

Authors:  R H Scheuermann; E Racila; T Tucker; E Yefenof; N E Street; E S Vitetta; L J Picker; J W Uhr
Journal:  Proc Natl Acad Sci U S A       Date:  1994-04-26       Impact factor: 11.205

8.  BCL1, a murine model of prolymphocytic leukemia. I. Effect of splenectomy on growth kinetics and organ distribution.

Authors:  M J Muirhead; P C Isakson; K A Krolick; J W Uhr; E S Vitetta
Journal:  Am J Pathol       Date:  1981-12       Impact factor: 4.307

9.  Induction of tumor immunity by intact irradiated leukemic B cells (BCL1) bearing a tumor-associated cell-surface idiotype and the costimulatory B7 molecule.

Authors:  S Morecki; S Levi; Y Puyesky; S Slavin
Journal:  Cancer Immunol Immunother       Date:  1995-10       Impact factor: 6.968

10.  In vivo therapy of a murine B cell tumor (BCL1) using antibody-ricin A chain immunotoxins.

Authors:  K A Krolick; J W Uhr; S Slavin; E S Vitetta
Journal:  J Exp Med       Date:  1982-06-01       Impact factor: 14.307
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