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Literature DB >> 6987174

Ganglioside and monosaccharide inhibition of nonspecific lymphocyte mitogenicity by group A streptococcal pyrogenic exotoxins.

P M Schlievert, D J Schoettle, D W Watson.

Abstract

Group A streptococcal pyrogenic exotoxins (SPE) types A, B, and C are potent nonspecific lymphocyte mitogens. The mitogenicity of these exotoxins was inhibited by gangliosides and sialic acid, whereas concanavalin A was unaffected. The capacity of both concanavalin A and SPE-A to stimulate lymphocytes was suppressed by alpha-methyl-D-mannopyranoside. Galactose reduced the activity of SPE-C. The sugars, glucose, N-acetylglucosamine, alpha-methyl-D-glucopyranoside, and fucose, did not affect SPE mitogenicity.

Entities: Chemical

Mesh：

Substances：

Year: 1980 PMID： 6987174 PMCID： PMC550757 DOI： 10.1128/iai.27.1.276-279.1980

Source DB: PubMed Journal: Infect Immun ISSN： 0019-9567 Impact factor: 3.441

20 in total

6. The effect of N acetyl C-galactosamine and other sugars on the mitogenic activity and attachment of PHA to tonsil cells.

Authors: H Borberg; I Yesner; B Gesner; R Silber
Journal: Blood Date: 1968-06 Impact factor: 22.113

7. Reversible interaction of human lymphocytes with the mitogen concanavalin A.

Authors: A E Powell; M A Leon
Journal: Exp Cell Res Date: 1970-10 Impact factor: 3.905

8. Isolation of a human lymphocyte mitogen from wheat germ with N-acetyl-D-glucosamine specificity.

Authors: J M Brown; M A Leon; J J Lightbody
Journal: J Immunol Date: 1976-11 Impact factor: 5.422

9. A purified group A streptococcal pyrogenic exotoxin. Physiochemical and biological properties including the enhancement of susceptibility to endotoxin lethal shock.

Authors: Y B Kim; D W Watson
Journal: J Exp Med Date: 1970-03-01 Impact factor: 14.307

10. Host-parasite factors in group A streptococcal infections. Pyrogenic and other effects of immunologic distinct exotoxins related to scarlet fever toxins.

Authors: D W WATSON
Journal: J Exp Med Date: 1960-02-01 Impact factor: 14.307

3 in total

Ganglioside and monosaccharide inhibition of nonspecific lymphocyte mitogenicity by group A streptococcal pyrogenic exotoxins.

1. Further studies of group A streptococcal factors with lethal and cardiotoxic properties.

2. The fixation of tetanus toxin, strychnine, serotonin and other substances by ganglioside.

3. Nonspecific T-lymphocyte mitogenesis by pyrogenic exotoxins from group A streptococci and Staphylococcus aureus.

4. Enhanced immune response after immunosuppression by Streptococcal pyrogenic exotoxin.

5. Deactivation of cholera toxin by ganglioside.

6. The effect of N acetyl C-galactosamine and other sugars on the mitogenic activity and attachment of PHA to tonsil cells.

7. Reversible interaction of human lymphocytes with the mitogen concanavalin A.

8. Isolation of a human lymphocyte mitogen from wheat germ with N-acetyl-D-glucosamine specificity.

9. A purified group A streptococcal pyrogenic exotoxin. Physiochemical and biological properties including the enhancement of susceptibility to endotoxin lethal shock.

10. Host-parasite factors in group A streptococcal infections. Pyrogenic and other effects of immunologic distinct exotoxins related to scarlet fever toxins.

1. Purification and characterization of Clostridium perfringens delta-toxin.

2. Activation of murine T-suppressor lymphocytes by group A streptococcal and staphylococcal pyurogenic exotoxins.

Review 3. Staphylococcal and streptococcal superantigen exotoxins.