Literature DB >> 2001716

Molecular parasitology: progress towards the development of vaccines for malaria, filariasis, and schistosomiasis.

S J Cryz1.   

Abstract

Advances in molecular biology have allowed for the identification of potential vaccine candidates against several parasitic diseases. Antigens from various life stages of Plasmodium and Schistosoma species and filarial worms have been cloned, sequenced and tested as vaccines. Results to date in animal models have been promising. Modest levels of protection against experimental human malaria have been obtained using both sporozoite and blood-stage antigens. However, a greater understanding of the mechanisms which lead to immunity against parasites is required before effective vaccines can be developed.

Entities:  

Mesh：

Substances：

Year:  1991        PMID： 2001716     DOI： 10.1007/bf01945415

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  45 in total

1.  Immunogenicity of synthetic peptides from circumsporozoite protein of Plasmodium falciparum.

Authors:  W R Ballou; J Rothbard; R A Wirtz; D M Gordon; J S Williams; R W Gore; I Schneider; M R Hollingdale; R L Beaudoin; W L Maloy
Journal:  Science       Date:  1985-05-24       Impact factor: 47.728

2.  Human T-cell recognition of the circumsporozoite protein of Plasmodium falciparum: immunodominant T-cell domains map to the polymorphic regions of the molecule.

Authors:  M F Good; D Pombo; I A Quakyi; E M Riley; R A Houghten; A Menon; D W Alling; J A Berzofsky; L H Miller
Journal:  Proc Natl Acad Sci U S A       Date:  1988-02       Impact factor: 11.205

3.  Hybridoma produces protective antibodies directed against the sporozoite stage of malaria parasite.

Authors:  N Yoshida; R S Nussenzweig; P Potocnjak; V Nussenzweig; M Aikawa
Journal:  Science       Date:  1980-01-04       Impact factor: 47.728

4.  Dynamics of Schistosoma haematobium infection in a Gambian community. III. Acquisition and loss of infection.

Authors:  H A Wilkins; P H Goll; T F Marshall; P J Moore
Journal:  Trans R Soc Trop Med Hyg       Date:  1984       Impact factor: 2.184

5.  Observations on possible immunity to reinfection among Kenyan schoolchildren after treatment for Schistosoma mansoni.

Authors:  R F Sturrock; R Kimani; B J Cottrell; A E Butterworth; H M Seitz; T K Siongok; V Houba
Journal:  Trans R Soc Trop Med Hyg       Date:  1983       Impact factor: 2.184

6.  Induction of protection against Brugia malayi infection in jirds by microfilarial antigens.

Authors:  J W Kazura; H Cicirello; J W McCall
Journal:  J Immunol       Date:  1986-02-15       Impact factor: 5.422

7.  Protective immunity in bancroftian filariasis. Selective recognition of a 43-kD larval stage antigen by infection-free individuals in an endemic area.

Authors:  D O Freedman; T B Nutman; E A Ottesen
Journal:  J Clin Invest       Date:  1989-01       Impact factor: 14.808

8.  Structure of the gene encoding the immunodominant surface antigen on the sporozoite of the human malaria parasite Plasmodium falciparum.

Authors:  J B Dame; J L Williams; T F McCutchan; J L Weber; R A Wirtz; W T Hockmeyer; W L Maloy; J D Haynes; I Schneider; D Roberts
Journal:  Science       Date:  1984-08-10       Impact factor: 47.728

9.  Successful vaccination of cats against Brugia pahangi with larvae attenuated by irradiation with 10 krad cobalt 60.

Authors:  P Oothuman; D A Denham; P B McGreevy; G S Nelson; R Rogers
Journal:  Parasite Immunol       Date:  1979       Impact factor: 2.280

10.  Immunity in human schistosomiasis mansoni. Regulation of protective immune mechanisms by IgM blocking antibodies.

Authors:  J Khalife; M Capron; A Capron; J M Grzych; A E Butterworth; D W Dunne; J H Ouma
Journal:  J Exp Med       Date:  1986-11-01       Impact factor: 14.307
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.