Literature DB >> 6984192

Excessive mineralization with growth plate closure in rats on chronic warfarin treatment.

P A Price, M K Williamson, T Haba, R B Dell, W S Jee.   

Abstract

Rats maintained for 8 months on a level of warfarin sufficient to decrease the vitamin K-dependent protein of bone (bone Gla protein) to 2% of normal have an excessive mineralization disorder characterized by complete fusion of the proximal tibial growth plate and cessation of longitudinal growth. The general features of this abnormality resemble the fetal warfarin syndrome in humans, a disorder also characterized by excessive mineralization of the growth plate. These excessive mineralization disorders may be caused by the decreased levels of bone Gla protein, a protein that potently inhibits mineralization in vitro.

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Year:  1982        PMID： 6984192      PMCID： PMC347422          DOI： 10.1073/pnas.79.24.7734

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  20 in total

1.  Characterization of a gamma-carboxyglutamic acid-containing protein from bone.

Authors:  P A Price; A A Otsuka; J W Poser; J Kristaponis; N Raman
Journal:  Proc Natl Acad Sci U S A       Date:  1976-05       Impact factor: 11.205

2.  Primary structure of the gamma-carboxyglutamic acid-containing protein from bovine bone.

Authors:  P A Price; J W Poser; N Raman
Journal:  Proc Natl Acad Sci U S A       Date:  1976-10       Impact factor: 11.205

3.  Cell kinetics and morphology of the growth plate in the normal and hypophysectomized rat.

Authors:  K G Thorngren; L I Hansson
Journal:  Calcif Tissue Res       Date:  1973

4.  Effect of calcitonin on the rates of bone formation and resorption in the rat.

Authors:  D Baylink; E Morey; C Rich
Journal:  Endocrinology       Date:  1969-02       Impact factor: 4.736

Review 5.  Tetracycline-based histological analysis of bone remodeling.

Authors:  H M Frost
Journal:  Calcif Tissue Res       Date:  1969

6.  Formation, mineralization, and resorption of bone in vitamin D-deficient rats.

Authors:  D Baylink; M Stauffer; J Wergedal; C Rich
Journal:  J Clin Invest       Date:  1970-06       Impact factor: 14.808

7.  Role of the mitochondrion in the regulation of protein synthesis in the eucaryote Saccharomyces cerevisiae.

Authors:  P P Puglisi; A Algeri
Journal:  Mol Gen Genet       Date:  1971

8.  Ethane-1-hydroxy-1, 1-diphosphonate (EHDP). Effects on growth and modeling of the rat tibia.

Authors:  S C Miller; W S Jee
Journal:  Calcif Tissue Res       Date:  1975-09-05

9.  Vitamin K dependent modifications of glutamic acid residues in prothrombin.

Authors:  J Stenflo; P Fernlund; W Egan; P Roepstorff
Journal:  Proc Natl Acad Sci U S A       Date:  1974-07       Impact factor: 11.205

10.  Direct identification of the calcium-binding amino acid, gamma-carboxyglutamate, in mineralized tissue.

Authors:  P V Hauschka; J B Lian; P M Gallop
Journal:  Proc Natl Acad Sci U S A       Date:  1975-10       Impact factor: 11.205
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  40 in total

Review 1.  Bone matrix proteins: their function, regulation, and relationship to osteoporosis.

Authors:  Marian F Young
Journal:  Osteoporos Int       Date:  2003-03-12       Impact factor: 4.507

Review 2.  Endochondral bone growth, bone calcium accretion, and bone mineral density: how are they related?

Authors:  Kannikar Wongdee; Nateetip Krishnamra; Narattaphol Charoenphandhu
Journal:  J Physiol Sci       Date:  2012-05-25       Impact factor: 2.781

3.  Vitamin K2 promotes 1alpha,25(OH)2 vitamin D3-induced mineralization in human periosteal osteoblasts.

Authors:  Y Koshihara; K Hoshi; H Ishibashi; M Shiraki
Journal:  Calcif Tissue Int       Date:  1996-12       Impact factor: 4.333

4.  Induction of matrix Gla protein synthesis during prolonged 1,25-dihydroxyvitamin D3 treatment of osteosarcoma cells.

Authors:  J D Fraser; P A Price
Journal:  Calcif Tissue Int       Date:  1990-04       Impact factor: 4.333

Review 5.  Gamma-carboxyglutamate-containing proteins and the vitamin K-dependent carboxylase.

Authors:  C Vermeer
Journal:  Biochem J       Date:  1990-03-15       Impact factor: 3.857

6.  Immunocytochemical localization of BGP in human bones in various developmental stages and pathological conditions.

Authors:  T Ohta; M Mori; K Ogawa; T Matsuyama; S Ishii
Journal:  Virchows Arch A Pathol Anat Histopathol       Date:  1989

7.  Basic fibroblast growth factor as a selective inducer of matrix Gla protein gene expression in proliferative chondrocytes.

Authors:  Chantal Stheneur; Marie-France Dumontier; Claudie Guedes; Marie-Claude Fulchignoni-Lataud; Khadija Tahiri; Gerard Karsenty; Marie Thérèse Corvol
Journal:  Biochem J       Date:  2003-01-01       Impact factor: 3.857

8.  Articular-cartilage matrix gamma-carboxyglutamic acid-containing protein. Characterization and immunolocalization.

Authors:  R Loeser; C S Carlson; H Tulli; W G Jerome; L Miller; R Wallin
Journal:  Biochem J       Date:  1992-02-15       Impact factor: 3.857

Review 9.  Nonproliferative and Proliferative Lesions of the Rat and Mouse Skeletal Tissues (Bones, Joints, and Teeth).

Authors:  Stacey Fossey; John Vahle; Philip Long; Scott Schelling; Heinrich Ernst; Rogely Waite Boyce; Jacquelin Jolette; Brad Bolon; Alison Bendele; Matthias Rinke; Laura Healy; Wanda High; Daniel Robert Roth; Michael Boyle; Joel Leininger
Journal:  J Toxicol Pathol       Date:  2016-07-29       Impact factor: 1.628

10.  Effect of warfarin on early rat tooth development.

Authors:  I Gorter de Vries; E Wisse; M K Williamson; P A Price
Journal:  Calcif Tissue Int       Date:  1991-11       Impact factor: 4.333
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