Literature DB >> 6976853

Considerations about the structure-activity relationships of 8-aminoquinoline antimalarial drugs.

J D McChesney.   

Abstract

A discussion of the structure-activity relationships (SAR) of 8-aminoquinoline antimalarial drugs is presented. Consideration is given to the potential role of metabolic transformations in the in vivo activation of 8-aminoquinolines. It is emphasized that the mechanism of action of 8-aminoquinoline agents has not yet been established and thus any analysis of SAR must be speculative.

Entities:  

Mesh：

Substances：

Year:  1981        PMID： 6976853      PMCID： PMC2396068     

Source DB:  PubMed          Journal:  Bull World Health Organ        ISSN： 0042-9686            Impact factor:   9.408


  6 in total

1.  Synthesis of 2-substituted primaquine analogues as potential antimalarials.

Authors:  R V Shetty; C D Blanton
Journal:  J Med Chem       Date:  1978-09       Impact factor: 7.446

2.  Modifications of primiaquine as antimalarials. 2. 5-Phenylthio and 5-anilino derivatives of primaquine.

Authors:  K Tanabe; E H Chen; B L Verma; A J Saggiomo; E A Nodiff
Journal:  J Med Chem       Date:  1978-01       Impact factor: 7.446

3.  Modifications of primaquine as antimalarials. 1. 5-Phenoxy derivatives of primaquine.

Authors:  E H Chen; A J Saggiomo; K Tanabe; B L Verma; E A Nodiff
Journal:  J Med Chem       Date:  1977-08       Impact factor: 7.446

4.  Comparison of the curative antimalarial activities and toxicities of primaquine and its d and l isomers.

Authors:  L H Schmidt; S Alexander; L Allen; J Rasco
Journal:  Antimicrob Agents Chemother       Date:  1977-07       Impact factor: 5.191

5.  4-[(Aminoalkyl)amino]-1,2-dimethoxynaphthalenes as antimalarial agents.

Authors:  S Archer; P Osei-Gyimah; S Silbering
Journal:  J Med Chem       Date:  1980-05       Impact factor: 7.446

6.  4,5-disubstituted primaquine analogs as potential antiprotozoan agents.

Authors:  H Burghard; C DeWitt Blanton
Journal:  J Pharm Sci       Date:  1980-08       Impact factor: 3.534
  6 in total
  1 in total

1.  Novel potent metallocenes against liver stage malaria.

Authors:  Joana Matos; Filipa P da Cruz; Élia Cabrita; Jiri Gut; Fátima Nogueira; Virgílio E do Rosário; Rui Moreira; Philip J Rosenthal; Miguel Prudêncio; Paula Gomes
Journal:  Antimicrob Agents Chemother       Date:  2011-12-12       Impact factor: 5.191
  1 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.