Literature DB >> 408489

Modifications of primaquine as antimalarials. 1. 5-Phenoxy derivatives of primaquine.

E H Chen, A J Saggiomo, K Tanabe, B L Verma, E A Nodiff.   

Abstract

Various 5-phenoxy derivatives of primaquine have been prepared which are more active and less toxic than the parent compound in murine and monkey antimalarial screens. An improved method for the phthalimido alkylation of amines is described.

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Year:  1977        PMID: 408489     DOI: 10.1021/jm00218a026

Source DB:  PubMed          Journal:  J Med Chem        ISSN: 0022-2623            Impact factor:   7.446


  1 in total

1.  Considerations about the structure-activity relationships of 8-aminoquinoline antimalarial drugs.

Authors:  J D McChesney
Journal:  Bull World Health Organ       Date:  1981       Impact factor: 9.408

  1 in total

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