Literature DB >> 6976847

Pharmacology of 8-aminoquinolines.

R S Grewal.   

Abstract

The 8-aminoquinolines were the first group of compounds to be synthesized specifically for their antimalarial activity. A large-scale research programme in the United States of America in the 1940s produced three new antimalarial drugs-pentaquine, isopentaquine, and primaquine -of which primaquine was the most effective. This article reviews knowledge on the activity of these 8-aminoquinolines against all stages of the malaria parasite and suggests their possible modes of action. The toxic effects and possible causal mechanisms are also outlined.

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Year:  1981        PMID： 6976847      PMCID： PMC2396079     

Source DB:  PubMed          Journal:  Bull World Health Organ        ISSN： 0042-9686            Impact factor:   9.408


  32 in total

1.  Plasmodium berghei and chemotherapy.

Authors:  J SCHNEIDER
Journal:  Indian J Malariol       Date:  1954-12

2.  Assay of antimalarials against the sporogony cycle of P. gallinaceum. II.

Authors:  M G NARAYANDAS; A P RAY
Journal:  Indian J Malariol       Date:  1954-06

3.  Studies on Plasmodium berghei Vincke and Lips, 1948. XXXI. Selection of a primaquine resistant strain.

Authors:  S PRAKASH; A K CHAKRABARTI; D S CHOUDHURY
Journal:  Indian J Malariol       Date:  1961-06

4.  The effects of antimalarial drugs on nucleic acid synthesis in vitro in Tetrahymena pyriformis.

Authors:  K A Conklin; P Heu; S C Chou
Journal:  Mol Pharmacol       Date:  1973-05       Impact factor: 4.436

5.  Gametocytemia in falciparum malaria. Eradication of gametocytemia with primaquine.

Authors:  S J Berman; K K Holmes
Journal:  JAMA       Date:  1971-01-11       Impact factor: 56.272

6.  Effects of pyrimethamine, chlorguanide, and primaquine against exoerythrocytic forms of a strain of chloroquine-resistant Plasmodium falciparum from Thailand.

Authors:  R D Powell; G J Brewer
Journal:  Am J Trop Med Hyg       Date:  1967-11       Impact factor: 2.345

7.  Plasmodium berghei: inhibited incorporation of AMP-8- 3 H into nucleic acids of erythrocyte-free malarial parasites by acridines, phenanthridines, and 8-aminoquinolines.

Authors:  C H Lantz; K Van Dyke
Journal:  Exp Parasitol       Date:  1972-04       Impact factor: 2.011

8.  The binding of primaquine, pentaquine, pamaquine, and plasmocid to deoxyribonucleic acid.

Authors:  L P Whichard; C R Morris; J M Smith; D J Holbrook
Journal:  Mol Pharmacol       Date:  1968-11       Impact factor: 4.436

9.  Morphological effects of 8-aminoquinolines on the exoerythrocytic stages of Plasmodium fallax.

Authors:  M Aikawa; R L Beaudoin
Journal:  Mil Med       Date:  1969-09       Impact factor: 1.437

10.  Primaquine-induced changes in morphology of exoerythrocytic stages of malaria.

Authors:  R L Beaudoin; M Aikawa
Journal:  Science       Date:  1968-06-14       Impact factor: 47.728
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  8 in total

Review 1.  Treatment of malaria--1990.

Authors:  D M Panisko; J S Keystone
Journal:  Drugs       Date:  1990-02       Impact factor: 9.546

2.  Activity of clindamycin with primaquine against Pneumocystis carinii in vitro and in vivo.

Authors:  S F Queener; M S Bartlett; J D Richardson; M M Durkin; M A Jay; J W Smith
Journal:  Antimicrob Agents Chemother       Date:  1988-06       Impact factor: 5.191

3.  Nonrandomized controlled trial of artesunate plus sulfadoxine-pyrimethamine with or without primaquine for preventing posttreatment circulation of Plasmodium falciparum gametocytes.

Authors:  Naman K Shah; Allan Schapira; Jonathan J Juliano; Bina Srivastava; Pia D M MacDonald; Charles Poole; Anup Anvikar; Steven R Meshnick; Neena Valecha; Neelima Mishra
Journal:  Antimicrob Agents Chemother       Date:  2013-04-15       Impact factor: 5.191

4.  Activities of artesunate and primaquine against asexual- and sexual-stage parasites in falciparum malaria.

Authors:  Sasithon Pukrittayakamee; Kesinee Chotivanich; Arun Chantra; Ralf Clemens; Sornchai Looareesuwan; Nicholas J White
Journal:  Antimicrob Agents Chemother       Date:  2004-04       Impact factor: 5.191

5.  NPC1161B, an 8-Aminoquinoline Analog, Is Metabolized in the Mosquito and Inhibits Plasmodium falciparum Oocyst Maturation.

Authors:  Timothy Hamerly; Rebecca E Tweedell; Bernadette Hritzo; Vincent O Nyasembe; Babu L Tekwani; N P Dhammika Nanayakkara; Larry A Walker; Rhoel R Dinglasan
Journal:  Front Pharmacol       Date:  2019-10-25       Impact factor: 5.810

Review 6.  Is it time for Africa to adopt primaquine in the era of malaria control and elimination?

Authors:  Richard O Mwaiswelo; Hamis Kabuga; Eliningaya J Kweka; Vito Baraka
Journal:  Trop Med Health       Date:  2022-02-25

7.  A randomized open-label trial of artesunate- sulfadoxine-pyrimethamine with or without primaquine for elimination of sub-microscopic P. falciparum parasitaemia and gametocyte carriage in eastern Sudan.

Authors:  Badria El-Sayed; Salah-Eldin El-Zaki; Hamza Babiker; Nahla Gadalla; Tellal Ageep; Fathi Mansour; Omer Baraka; Paul Milligan; Ahmed Babiker
Journal:  PLoS One       Date:  2007-12-12       Impact factor: 3.240

8.  A single low dose of primaquine is safe and sufficient to reduce transmission of Plasmodium falciparum gametocytes regardless of cytochrome P450 2D6 enzyme activity in Bagamoyo district, Tanzania.

Authors:  Richard Owden Mwaiswelo; Billy Ngasala; Dominick Msolo; Eliningaya Kweka; Bruno P Mmbando; Andreas Mårtensson
Journal:  Malar J       Date:  2022-03-12       Impact factor: 2.979
  8 in total

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