Literature DB >> 5648260

Primaquine-induced changes in morphology of exoerythrocytic stages of malaria.

R L Beaudoin, M Aikawa.   

Abstract

Exposure to primaquine for 48 hours caused lesions in the exoerythrocytic stages of Plasmodium fallax grown in cultivated cells derived from embryonic turkey brain. The lesions appeared in the form of cytoplasmic vacuoles when viewed under the light microscope. The electron microscope revealed these vacuoles as swollen mitochondria readily identifiable by their typical protozoan cristae. Mitochondria of the host cell were unaffected.

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Year:  1968        PMID： 5648260     DOI： 10.1126/science.160.3833.1233

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  12 in total

1.  Parasite cultivation in relation to research on the chemotherapy of malaria.

Authors:  P I Trigg
Journal:  Bull World Health Organ       Date:  1976       Impact factor: 9.408

2.  Effect of the 8-aminoquinoline primaquine on culture-derived gametocytes of the malaria parasite Plasmodium falciparum.

Authors:  H N Lanners
Journal:  Parasitol Res       Date:  1991       Impact factor: 2.289

Review 3.  [Biochemistry of some parasitic helminths and protozoa and the mode of action of some antiparasitic drugs].

Authors:  H Metzger
Journal:  Z Parasitenkd       Date:  1970

Review 4.  Infectious diseases. Annual review of significant publications.

Authors:  H A Reimann
Journal:  Postgrad Med J       Date:  1969-07       Impact factor: 2.401

5.  Pharmacology of 8-aminoquinolines.

Authors:  R S Grewal
Journal:  Bull World Health Organ       Date:  1981       Impact factor: 9.408

6.  Inhibition of precursor incorporation into nucleic acids of mammalian tissues by antimalarial aminoquinolines.

Authors:  R C Field; B R Gibson; D J Holbrook; B M McCall
Journal:  Br J Pharmacol       Date:  1978-02       Impact factor: 8.739

7.  Defining the timing of action of antimalarial drugs against Plasmodium falciparum.

Authors:  Danny W Wilson; Christine Langer; Christopher D Goodman; Geoffrey I McFadden; James G Beeson
Journal:  Antimicrob Agents Chemother       Date:  2013-01-14       Impact factor: 5.191

8.  Effects of 8-aminoquinolines on the ultrastructural morphology of Pneumocystis carinii.

Authors:  M P Goheen; M S Bartlett; M M Shaw; S F Queener; J W Smith
Journal:  Int J Exp Pathol       Date:  1993-08       Impact factor: 1.925

9.  Is serial testing required to diagnose imported malaria in the era of rapid diagnostic tests?

Authors:  Janet M Pasricha; Surender Juneja; Joseph Manitta; Susan Whitehead; Ellen Maxwell; Wai-Keong Goh; Sant-Rayn Pasricha; Damon P Eisen
Journal:  Am J Trop Med Hyg       Date:  2012-12-03       Impact factor: 2.345

10.  The antimalarial drug primaquine targets Fe-S cluster proteins and yeast respiratory growth.

Authors:  Anaïs Lalève; Cindy Vallières; Marie-Pierre Golinelli-Cohen; Cécile Bouton; Zehua Song; Grzegorz Pawlik; Sarah M Tindall; Simon V Avery; Jérôme Clain; Brigitte Meunier
Journal:  Redox Biol       Date:  2015-11-26       Impact factor: 11.799
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